XB-FEAT-485833

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tlx1

This is the community wiki page for the gene tlx1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

12/18/2017

Human name has changed for Entrez Gene: 3195. From T-cell leukemia homeobox 1 to T cell leukemia homeobox 1

NCBI Summary

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]