XB-FEAT-953989

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mcc

This is the community wiki page for the gene mcc please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature issues

05.14.2018 Human name has changed for Entrez Gene: 4163. From mutated in colorectal cancers to MCC, WNT signaling pathway regulator.

summary from NCBI

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]