XB-FEAT-962426

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top1mt

This is the community wiki page for the gene top1mt please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

08/07/2017

Human name has changed for Entrez Gene: 116447. From topoisomerase (DNA) I, mitochondrial to DNA topoisomerase I mitochondrial

summary from NCBI

This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]