XB-FEAT-976380

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rbfox3

This is the community wiki page for the gene rbfox3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

undated change: Human symbol has changed for Entrez Gene: 146713: from hrnbp3 to rbfox3

09/24/2017 Human name has changed for Entrez Gene: 146713. From RNA binding protein, fox-1 homolog 3 to RNA binding fox-1 homolog 3

summary from NCBI

This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]