XB-FEAT-960657

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atp2b2

This is the community wiki page for the gene atp2b2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.


gene annotation corrections

19APRIL2023

The gene names and designations for atp2b2 and atp2b4 have been reassessed.

Based on Synteny with human, it appears these genes in Xenopus had been mis-labelled, and are now corrected here.

Xenopus at2b2 genes are on Chr4/4L4S, and do not share the same flanking genes present in mammals.


Human CHR3: GHRLOS> GHRL< SEC13< ATP2B2< SLC6A1> SLC6A11> HRH1>

Xtrop Chr4: aspn> omd> ogn> nol8> iars1> atp2b2> fancd2>

Xla chr4L: ogn.l> nol8.L> iars1.L> atp2b2.L> fancd2.L> fancd2os.L< fancd2os<

Zfish chr17: rpl29> iars1> atp2b2> slca11b> slc6a1b> atg7>


Xenopus atp2b4 genes are on Chr2/2S ( not present on X. laevis 2L) and share a conserved synteic gene patern with mammals, and lesser extent fish. These are the true orthologs of human ATP2B4.


HUMAN CHR1: FMOD< PRELP> OPTC> ATP2B4> LAX1> ZC3H11A/ZBED6> SNRPE>

Xtrop Chr2: srpk1< mapk14> zc3h11a< LOC100488346|atp2b4< optc< prelp< fmod>

Xla chr2S: srpk1.S< mapk14.S> zc3h11a.S< LOC108709452|atp2b4< optc.S< prelp.S< fmod.S>

Zfish chr11: kiss1> csf1a< optc> atp2b4> mdm4> LOC< myog> ppfia4<

nomenclature changes

19APRIL2023

X. tropicalis Gene ID 100488346 [XB-GENE-950177] change from atp2b2, ATPase, Ca++ transporting, plasma membrane 2 to atp2b4, ATPase plasma membrane Ca2+ transporting 4

X. laevis Gene ID 108709452 [XELAEV_18014870mg] change from LOC108709452, plasma membrane calcium-transporting ATPase 4 to atp2b4.S, ATPase plasma membrane Ca2+ transporting 4 S homeolog

X. tropicalis Gene ID: 100487776 [XB-GENE-960658] change from atp2b4, ATPase, Ca++ transporting, plasma membrane 4 to atp2b2, ATPase plasma membrane Ca2+ transporting 2

X. laevis Gene ID: 446855 [XELAEV_18023767mg] change from atp2b4.L, ATPase, Ca++ transporting, plasma membrane 4 L homeolog to atp2b2.L, ATPase plasma membrane Ca2+ transporting 2 L homeolog

X. laevis Gene ID: 108715812 [XELAEV_18025751mg] change from atp2b4.S, ATPase, Ca++ transporting, plasma membrane 4 S homeolog to atp2b2.S, ATPase plasma membrane Ca2+ transporting 2 S homeolog