Hydroxyurea

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Description

Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.[1]

Hydroxyurea structure, image from NCBI Pubchem

Alternative Names

  • Hydroxycarbamide
  • N-Hydroxyurea
  • Hydrea
  • Onco-carbide

Chemical Name

Hydroxyurea

Suppliers

Sigma

References