XB-FEAT-877066

rnf128

This is the community wiki page for the gene rnf128 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

05.13.19 Human name has changed for Entrez Gene: 79589. From ring finger protein 128, E3 ubiquitin protein ligase to ring finger protein 128

Summary from NCBI for human RF128

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]