Suramin

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Description

synonyms: Germanin; Naganol; Naphuride; Belganyl; Suramine

"Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity."

  • -Sigma product description
suramin structure, photo from pubchem

Genes Affected

Topoisomerase II

Suppliers

Usage Notes

150mM in culture

References

>209 Xenbase articles contain a reference to suramin according to textpresso