XB-FEAT-5767839

pnmt.2

This is the community wiki page for the gene pnmt.2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

26April2023

Xenopus gene symbol changed from mgc107884 to pnmt.2

Xenopus gene name changed from mgc107884 protein to phenylethanolamine N-methyltransferase gene 2

orthology

there are 2 PNMT orthologs in Xenopus:

1) pnmt phenylethanolamine N-methyltransferase [ Xenopus tropicalis (tropical clawed frog) ] Gene ID: 100492236,XP_002940421.1 on Chromsome 10/9_10L/9_10S

2) uncharacterized protein LOC548447 [Xenopus tropicalis] XB-GENE-5767840 GeneId:548447 NCBI Reference Sequence: NP_001015730.1 on Chr 5.

DIOPT/EggNog finds that both proteins are part of the NNMT/PNMT/TEMT family of proteins.

This 2nd gene on Chr5 in Xtrop is therefore called PNMT gene 2 going forward .

A closer look at syteny is need to see if there are other uncharacterized genes in X.laevis that belong on this gene page.

proteins

1)

>XP_002940421.1 phenylethanolamine N-methyltransferase [Xenopus tropicalis] MSNVESVAQSYQQFNPRAYLQNNYVPPRADFSNEGSVVQWKLRCLADACATGEIGGHTLVDIGSGPTIYQ ILSASEHFKEVVLTDYLEVNRAELRRWLQDEPGAFDWSPYIKHVSKLEGRGDSWQEKQKRIRERVKTVLP VDVHQPNPLGEEISSGSVDALVSTFCLEACSPNLEMFHRALGNITKLLKPGGHLLFIGALEESYYLAGEA KLNVVPVTEEIVRNALSDASYKIKEFKTYIMPPTLKVGVDDVNGVFFAWAQKQDSK

2) uncharacterized protein LOC548447 [Xenopus tropicalis] on Chromosome 5 NCBI Reference Sequence: NP_001015730.1

>NP_001015730.1 uncharacterized protein LOC548447 [Xenopus tropicalis] MSFTGGERYQSKFDPKAYLASFCSLGKGRDKIMNFRFQKCFETFGPGGIRGDTLIDIGTGPSIYQLVSAC ESFKNIIATDFTDSNRQEFQKWLKSEPGSFDWSETLKTVCEIEGNRENWREKENKLRATIKKVLKCDVTN SNPLHPEVLPKADCLITALCLETACKDIDAYKDAMRNITTLLKPGGHLVVIGVLGDSFYKVGKQKFFCLP LDEETVRNTVLNAGYTIKELDVFPIDNMSLHADITDSYANFFLVAKKNLT