XB-FEAT-5959819

gpr4l

This is the community wiki page for the gene gpr4l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

18OCT23

Xenopus gene changed from MGC69520 , Novel 7 transmembrane receptor (rhodopsin family) protein to gpr4l.2, G protein-coupled receptor 4 like gene 2.

This change was motivated to replace the MGC# symbol with something more meaningful, and was based on lack of synteny to true grp4 (see below) and a DIOPT/EggNog analysis, which aligned the protein to GPR4 in ~100 other species with very high confidence and similarity.

Although on the same chromosome as true gpr4 gene, these 2 genes are not adjacent to true gpr4, and therefore are not considered as gpr4 duplicates ( in which case they could be named gpr4.2 and grp4.3), but will be provisionally called 'like' genes.

XB5959819 symbol changed to grp4l.1/gpr4l

MGC69520 symbol changed to grp4l.2

synteny

18OCT23

Note that true orthologs of GPR4 are flanked by elm1/2 and opa3 , while these grp4-like genes are flanked by shkbp1 and sptbn4.

Human: chr19: VASP> OPA3< GPR4< EML2< EML2-AS1>

ZFISH: CHR15: nova2> polr1g< gpr4< eml2< gipr>

Xtrop.chr8: fbxo46< gipr< eml1> gpr4> opa3>

Xtrop v10.chr8: shkbp1< XB5959819> MGC69520> sptbn4<

Annotation notes: XB5959819 and MGC69520 may end u/require merging as they seem to be partial/fragmented sequence accessions of the same gene. In this case, I still think the merged model should be grp4-like based on EggNog 5.0 analysis which matches both to the GRP4 protein tree.