XB-FEAT-5968249

dok1

This is the community wiki page for the gene dok1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomencalture changes

the synonym Xdpcp  stands for Xenopus dok-PTB containing protein.

functional notes

from XB-ART-39594: - dok1/Xdpcp has a pivotal role in regulating mesendoderm formation in Xenopus, and negatively regulates the activin/nodal signaling pathway.

-dok1/Xdpcp is strongly expressed in the animal hemisphere at the cleavage and blastula stages.

-The overexpression of dok1/xdpcp RNA affects activin/nodal signaling, which causes defects in mesendoderm formation.

-loss of dok1/Xdpcp function by injection of morpholino oligonucleotides leads to the expansion of the mesodermal territory

- dok1/Xdpcp inhibits the phosphorylation and nuclear translocation of Smad2

-dok1/Xdpcp interacts with Alk4, a type I activin receptor, and inhibits activin/nodal signaling by disturbing the interaction between Smad2 and Alk4.

- taken together, these results indicate that dok1/ Xdpcp regulates activin/nodal signaling that is essential for mesendoderm specification.