XB-FEAT-960392

ptpn21

This is the community wiki page for the gene ptpn21 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

05.13.19

Human name has changed for Entrez Gene: 11099. From protein tyrosine phosphatase, non-receptor type 21 to protein tyrosine phosphatase non-receptor type 21

Summary from NCBI for human PTPN21

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]