XB-FEAT-986140

nectin1

This is the community wiki page for the gene nectin1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

11/07/2016 Human symbol has changed for genepage ID: 986140 From pvrl1 to NECTIN1

Human symbol has changed for Entrez Gene: 5818. From PVRL1 to NECTIN1

Human name has changed for Entrez Gene: 5818. From poliovirus receptor-related 1 (herpesvirus entry mediator C) to nectin cell adhesion molecule 1

latest research

Ablain, J., Al Mahi, A., Rothschild, H. et al. Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nat Genet 54, 1839–1852 (2022). https://doi.org/10.1038/s41588-022-01191-z

Few genetic alterations have been linked to metastasis, during which cancer cells acquire abnormal migratory behavior. THIS new study [in human patients] sheds light on how loss of NECTIN1 leads to melanoma dissemination after local depletion of IGF1.

Cells acquire a combination of mutations and transcriptional changes for tumor initiation, dissemination, colonization and growth at a secondary site. Genomics-based efforts have identified tumor-suppressor and oncogenic pathways that lead to cell transformation and the formation of primary tumors. However, very few alterations have been described in the context of tumor spreading, with some recent studies finding similar mutational landscapes between primary tumors and metastases1.

A new study in Zebrafish (see Nature Genetics issue 54, 2022) identifies the loss of NECTIN1 as a common event in patients with melanoma2. Using The Cancer Genome Atlas (TCGA) dataset (363 patients), Ablain et al.2 analyzed copy number alterations and observed that the third most significant focal deletion at chr11q23.3 contained only the gene NECTIN1. Bi-allelic loss of NECTIN1 was found in 4.4% of patients, and 50% of melanomas exhibited shallow deletions. Using immunohistochemistry approaches, the authors showed that levels of NECTIN1 protein are lower in patients with metastatic melanoma2, which suggests a link between loss of NECTIN1 function and tumor dissemination.