XB-FEAT-986526

hsd3b7l

This is the community wiki page for the gene hsd3b7l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

Xenopus gene symbol changed from loc100494546 to XB986526 [provisional:hsd3b7]

05May2023

Xenopus gene name changed from provisional ortholog of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 to hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 like

Xenopus gene symbol changed from XB986526 [provisional:hsd3b7] to hsd3b7l

background to nomenclature changes

Jan/05/23

HSD3B7 symbol applied to wrong chicken gene ( and thus the wrong Xenopus gene)

reported by David Webb from NCBI RefSeq team. RSCOM-393

Chicken GeneID: 417505 is named HSD3B7 (CGNC:1253) but isn't truly orthologous to human HSD3B7 (GeneID:80274).

Xenopus has an unnamed gene (GeneID: 100494546, XB-GENE-986527) that is the ortholog of the misnamed chicken GeneID: 417505.

chicken GeneID: 417505 resides at:

IFT22< COL26A1> "'HSD3B7'"> MYL10< CUX1>

while human is at:

FBXL19> ORAI3> SETD1A> HSD3B7> STX1B< STX4> ZNF668<

I think what's happening is that the true HSD3B7 gene is difficult to sequence and assemble in birds & crocodilians and so a similar gene, which mammals have lost, is being misnamed as "HSD3B7" in many non-mammals.

In addition to mammals, this "HSD3B7" gene is also lost in squamates and caecilians though frogs, coelacanth & lungfish (Protopterus annectens) have both genes which suggests ancestral sarcopterygians had both HSD3B7 and '"HSD3B7-like'".

The true HSD3B7 gene is older and goes back to vertebrata (and likely further) while "HSD3B7 like" arose in sarcopterygians.

So my recommendations are:

Gga GeneID: 417505 (CGNC:1253) needs to be renamed from HSD3B7 to something else (HSD3B7L? HSD3B8 and HSD3B9 are already used in mouse).

Gga GeneID: 121108723 (CGNC:88598, HSD3B7L) should be named HSD3B7 (XP_040512766.1, lacks roughly aa 186-366 from the C-terminus).

Xtr GeneID: 100145626 XB-GENE-1008841 is correctly named hsd3b7

Xtr GeneID: 100494546 XB-GENE-986527 needs to be named to match chicken GeneID: 417505/"HSD3B7like"

Dre GeneID: 327462 ZDB-GENE-030131-5673 is correctly named hsd3b7