ZM 447439

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Description

"Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells."

  • -Tocris product description
ZM 447439 structure, photo from Pubchem

Genes Affected

Suppliers

Usage Notes

20uM

References

>1 Xenbase articles contain a reference to ZM 447439 according to textpresso