XB-FEAT-984452: Difference between revisions
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This is the community wiki page for the gene ''masp1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''masp1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | =nomenclature changes= | ||
gene name changed from ''mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)'', to ''mannan-binding lectin serine peptidase 1'' | |||
NB: ''Xenopus'' gene names follow human nomenclature. | |||
date unknown | |||
''Xenopus'' gene name changed from ''mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)'', to mannan-binding lectin serine peptidase 1 | |||
date unknown | |||
''Xenopus'' name has changed for Entrez Gene: 5648. From mannan-binding lectin serine peptidase 1 to mannan binding lectin serine peptidase 1 ( removed the hyphen!) | |||
opus | |||
2.17.2021 | |||
''Xenopus'' name has changed for Entrez Gene: 5648. From mannan binding lectin serine peptidase 1 to MBL associated serine protease 1 | |||
=Summary for human MASP1 from NCBI= | =Summary for human MASP1 from NCBI= | ||
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] | This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] | ||
Revision as of 15:25, 23 February 2021
masp1
This is the community wiki page for the gene masp1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
NB: Xenopus gene names follow human nomenclature.
date unknown
Xenopus gene name changed from mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor), to mannan-binding lectin serine peptidase 1
date unknown
Xenopus name has changed for Entrez Gene: 5648. From mannan-binding lectin serine peptidase 1 to mannan binding lectin serine peptidase 1 ( removed the hyphen!) opus
2.17.2021
Xenopus name has changed for Entrez Gene: 5648. From mannan binding lectin serine peptidase 1 to MBL associated serine protease 1
Summary for human MASP1 from NCBI
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]