XB-FEAT-29085838

adam33

This is the community wiki page for the gene adam33 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

13SEPT2023

Following a review by Xenbase and the NCBIref seq team, the Xenopus gene name has changed from LOC101732075, disintegrin and metalloproteinase domain-containing protein 12 to adam33, ADAM metallopeptidase domain 33

By synteny, the true Xtropicalis ortholog of human ADAM33 is Xenopus GeneID: 101732075 (XB-GENE-29085839) along with X. laevis.L GeneID: 108697349 & X. laevis.S & GeneID: 108704093.

summary for HUMAN ADAM33 from NCBI

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

synteny

Xtr.adam33 chr1: lyrm2 hspa12b c20orf27 spef1 GeneID:101732075/LOC101732075 cdc25b znf638 loc100488564 cyp26b1 exoc6b

Xla.adam33.L chr1L: LOC121401575 LOC108697270 znf638.L LOC108697345 cdc25b.L GeneID:108697349/LOC108697349 spef1.L LOC108719387 hspa12b.L lyrm2.L LOC108719395

Xla.adam33.S chr1S: vax2.S exoc6b.S cyp26b1.S znf638.S cdc25b.S GeneID:108704093/LOC108704093 spef1.S c20orf27.S lyrm2.S LOC121399259 XB22166511.S