XB-FEAT-5793162

gpr12

This is the community wiki page for the gene gpr12 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

15MAY2023

Xenopus gene (XB-GENEPAGE-5793162; Chr.2/2L/2S) was changed to gpr12 from gpr185a; and gene (XB-GENEPAGE-995706; Chr.8/8L/8S) was changed to gpr12l from gpr12. This decision was made with evidence from orthology and synteny:

XP_004912099 - previously gpr185a - X. tropicalis (NCBI ID:100493845) → TRUE gpr12

XP_002931838 - previously gpr12 - X. tropicalis (NCBI ID:100488444) → should be gpr12l ("-like")

XP_005173961 - gpr185a - D. rerio (NCBI ID:100329977)

XP_021325993 - gpr12 - D. rerio (NCBI ID:565609)

NP_005279 - GPR12 - H. sapiens (NCBI ID:2835)

X. tropicalis previously “gpr185a” (chr.2) - 100493845

fit3 urad cdx2 pdx1 gsx1 loc496835 lnx2 gtf3a rasl11a< rpl21< mtif3> usp12> NEW gpr12> wasf3< loc105946590> cdk8< atp8a2> shisa2< nup58 mtmr6 amer2

X. tropicalis previously “gpr12” (chr.8) - 100488444

kdrl> loc116406575< cdx4 chic1 fip1l1> lnx2< rasl11al< usp12b> loc116406779< NEW gpr12l> loc105948269< wasf3l< slc16a2> rlim< zdhhc15> uprt< endog>

D. rerio “gpr185a” (chr.21) - 100329977

tmem185< ankrd46a< atg4a> irs4a< si:ch73-362m14.2< gpr185a> si:ch73-362m14.4< htr2cl2< si:ch1073-263o8.2< si:dkey-229d11.5< si:ch211-268m18.4< loc110438210< tmlhe>

D. rerio “gpr12” (chr.24) - 565609

fit3 urad pdx1 si:ch211-140b10.6 lnx2a> gtf3ab rpl21 usp12a> gpr12> wasf3b< cdk8< rnf6> atp8a2> spice1>...shisa2<...spice1> loc10188469

H. sapiens “gpr12” (chr.13) - 2835

FLT3 URAD CDX2 PDX1 GSX1 POLR1D LNX2> MTIF3 GTF3A RASL11A RPL21 USP12> GPR12< WASF3< CDK8< RNF6 SHISA2 ATP8A2<

Synteny with human and Danio gpr12 genes supports assignments of genes to true gpr12 or gpr12l in Xenopus.

See also publication Li, Z., Jiang, B., Cao, B., et al. (2021). Characterization of Four Orphan Receptors (GPR3, GPR6, GPR12 and GPR12L) in Chickens and Ducks and Regulation of GPR12 Expression in Ovarian Granulosa Cells by Progesterone. Genes (Basel); 12: 489. doi: 10.3390/genes12040489.

- Authors of the cited article characterize among others a GPR12L ('like') gene in duck, chicken, quail, spotted gar and lizard.

- - curator AJB