AZD1480: Difference between revisions
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==Description== | ==Description== | ||
Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1. | Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1. | ||
[[File:azd1480.gif]] | [[File:azd1480.gif|frame|right|Structure of AZD1479, photo from Selleck Chemical]] | ||
**Genes Affected | **Genes Affected | ||
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==Suppliers== | ==Suppliers== | ||
*[https://pubchem.ncbi.nlm.nih.gov/compound/16659841 PubChem] | |||
*[http://www.selleckchem.com/products/azd1480.html Selleck Chemicals] | *[http://www.selleckchem.com/products/azd1480.html Selleck Chemicals] | ||
*[http://www.scbt.com/datasheet-364735-azd1480.html Santa Cruz ] | *[http://www.scbt.com/datasheet-364735-azd1480.html Santa Cruz ] | ||
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*[http://www.xenbase.org/literature/article.do?method=display&articleId=50713 Hyakutake et al., 2015] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=50713 Hyakutake et al., 2015] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42239 Bergmann et al., 2010] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=42239 Bergmann et al., 2010] | ||
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*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | |||
Latest revision as of 13:28, 2 June 2015
Description
Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
