AZD1480: Difference between revisions
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imported>Kevin (Created page with "==Description== Inhibits the Jak Stat pathway **Genes Affected **[http://www.xenbase.org/gene/showgene.do?method=display&geneId=483749 jak1] **[http://www.xenbase.org/gene/sh...") |
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==Description== | ==Description== | ||
Inhibits the Jak Stat pathway | Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1. | ||
[[File:azd1480.gif|frame|right|Structure of AZD1479, photo from Selleck Chemical]] | |||
**Genes Affected | **Genes Affected | ||
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==Suppliers== | ==Suppliers== | ||
Selleck Chemicals | *[https://pubchem.ncbi.nlm.nih.gov/compound/16659841 PubChem] | ||
Santa Cruz | *[http://www.selleckchem.com/products/azd1480.html Selleck Chemicals] | ||
*[http://www.scbt.com/datasheet-364735-azd1480.html Santa Cruz ] | |||
==Usage Notes== | ==Usage Notes== | ||
==References== | ==References== | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=50713 | *[http://www.xenbase.org/literature/article.do?method=display&articleId=50713 Hyakutake et al., 2015] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42239 | *[http://www.xenbase.org/literature/article.do?method=display&articleId=42239 Bergmann et al., 2010] | ||
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*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | |||
Latest revision as of 13:28, 2 June 2015
Description
Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
