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| ==Description== | | ==References]] |
| "Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."
| | *[http://www.xenbase.org/literature/article.do?method=display&articleId=50595 Wang et al., 2015] |
| *-Tocris Product Description
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| [[File:SB431542.png|frame|right|SB-431542 structure, photo from Sigma-Aldrich]]
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| ==Genes Affected==
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| *[http://www.xenbase.org/gene/showgene.do?method=displayGeneSummary&geneId=483903 ALK4 is a synonym for acvr1b]
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| *[http://www.xenbase.org/gene/showgene.do?method=display&geneId=478586 ALK5 is a synonym for tgfbr1]
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| *[http://www.xenbase.org/gene/showgene.do?method=display&geneId=487107 ALK7 is a synonym for acvr1c]
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| ==Suppliers==
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| *[http://www.tocris.com/dispprod.php?ItemId=54518#.VYQkcPlVhBc Tocris]
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| *[http://www.apexbt.com/sb-431542.html Apex]
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| *[https://www.caymanchem.com/app/template/Product.vm/catalog/13031 Cayman]
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| *[http://www.sigmaaldrich.com/catalog/product/sigma/s4317?lang=en®ion=US Sigma]
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| *[http://www.abcam.com/sb431542-ab120163.html abcam]
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| *[http://www.selleckchem.com/products/SB-431542.html Selleckchem]
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| ==Usage Notes==
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| ==References==
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| *[http://www.xenbase.org/literature/article.do?method=display&articleId=371 Ho et al., 2006] | |
| *[http://www.xenbase.org/literature/article.do?method=display&articleId=49634 Chiu 2014]
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| *[http://www.xenbase.org/literature/article.do?method=display&articleId=54570 Sato et al 2018]
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| *[https://pubchem.ncbi.nlm.nih.gov/compound/4521392 NCBI PubChem CID:4521392]
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| > 40 Xenbase articles contain a reference to SB431542 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
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| *
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| *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]
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