SB431542: Difference between revisions

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==Description==
==Description==
[[File:______|frame|right|_______ structure, photo from Sigma-Aldrich]]
"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."
 
*-Tocris Product Description
==Genes Affected==
 
==Suppliers==
*[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENBASE]
 
==Usage Notes==
 
==References==
*[https://pubchem.ncbi.nlm.nih.gov/ Pubchem]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=__________ ____ et al., 2xxxx]
 
>___ Xenbase articles contain a reference to _____ according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
*
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]


[[File:SB431542.png|frame|right|SB-431542 structure, photo from Sigma-Aldrich]]


==Genes Affected==
==Genes Affected==
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*[http://www.selleckchem.com/products/SB-431542.html Selleckchem]
*[http://www.selleckchem.com/products/SB-431542.html Selleckchem]


==references==
==Usage Notes==
 
==References==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=371 Ho et al., 2006]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=371 Ho et al., 2006]
* >23 other references within Xenbase use SB-431542 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search Textpresso]
*[https://pubchem.ncbi.nlm.nih.gov/ Pubchem]
 
>23 Xenbase articles contain a reference to SB-431542 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
*
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]

Revision as of 09:04, 19 June 2015

Description

"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."

  • -Tocris Product Description
SB-431542 structure, photo from Sigma-Aldrich

Genes Affected

Suppliers

Usage Notes

References

>23 Xenbase articles contain a reference to SB-431542 according to textpresso