Difference between revisions of "R-roscovitine"

From Xenbase
Jump to: navigation, search
(Created page with "==Description== "R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines,...")
(No difference)

Revision as of 12:26, 12 September 2019

Description

"R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore."

Source:

Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733


Olomoucine structure, photo from Sigma-Aldrich