From Xenbase
Revision as of 14:53, 8 March 2016 by Kevin (talk) (References)
Jump to: navigation, search


"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."

  • -Tocris Product Description
SB-431542 structure, photo from Sigma-Aldrich

Genes Affected


Usage Notes


>23 Xenbase articles contain a reference to SB-431542 according to textpresso