Small Molecules for Xenopus Research: Difference between revisions
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==Notice to our users== | |||
Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email. | |||
==Important small molecule references== | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=35021 Database of Small Molecules by Feldman and Hogue 2006] at [https://pubchem.ncbi.nlm.nih.gov/ PubChem] | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=47903 Wnt/Notch by Myers and Krieg 2014] | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=970 Ubiquitin-proteasome by Salic and King 2005] | |||
==Alphabetical List of Small Molecules With Literature References== | ==Alphabetical List of Small Molecules With Literature References== | ||
Line 7: | Line 15: | ||
*[[activin]] | *[[activin]] | ||
*[[AG1296]] | *[[AG1296]] | ||
*[[AG1879]] | |||
*[[AGN193109]] | *[[AGN193109]] | ||
*[[alpha-amanitin]] | *[[alpha-amanitin]] | ||
*[[anandamide]] | *[[anandamide]] | ||
*[[apelin]] | *[[apelin]] | ||
*[[aphidicolin ]] | *[[aphidicolin]] | ||
*[[AZD1480]] | *[[AZD1480]] | ||
*[[BAPTA-AM]] | *[[BAPTA-AM]] | ||
*[[BMS-453]] | |||
*[[beta-xyloside]] | *[[beta-xyloside]] | ||
*[[bumetanide]] | *[[bumetanide]] | ||
Line 20: | Line 30: | ||
*[[Chelerythrine]] | *[[Chelerythrine]] | ||
*[[chymostatin ]] | *[[chymostatin ]] | ||
*[[Colcemide]] | |||
*[[concanamycin]] | *[[concanamycin]] | ||
*[[cycloheximide]] | *[[cycloheximide]] | ||
*[[cyclopamine]] | *[[cyclopamine]] | ||
*[[Cyclosporin A]] | |||
*[[Cytochalasin B]] | *[[Cytochalasin B]] | ||
*[[cytochalasin D]] | |||
*[[Colcemide|Demecolcine]] | |||
*[[deltamethrin]] | |||
*[[dexamethosone]] | *[[dexamethosone]] | ||
*[[DHT(dihydrotestosterone)]] | *[[DHT(dihydrotestosterone)]] | ||
*[[diazepam]] | |||
*[[Ex-527]] | *[[Ex-527]] | ||
*[[forskolin]] | *[[forskolin]] | ||
Line 32: | Line 48: | ||
*[[GM6001]] | *[[GM6001]] | ||
*[[heptanol]] | *[[heptanol]] | ||
*[[herbimycin A]] | |||
*[[IBMX]] | *[[IBMX]] | ||
*[[jasplakinolide]] | |||
*[[KT 5720]] | *[[KT 5720]] | ||
*[[ | *[[lansoprazole]] | ||
*[[LiCl]] | *[[LiCl]] | ||
*[[Mg132]] | *[[Mg132]] | ||
*[[MMP-2 inhibitor II]] | *[[MMP-2 inhibitor II]] | ||
*[[nicorandil]] | *[[nicorandil]] | ||
Line 44: | Line 61: | ||
*[[NSC-87877]] | *[[NSC-87877]] | ||
*[[o-phenanthroline]] | *[[o-phenanthroline]] | ||
*[[okadaic acid]] | |||
*[[olomoucine]] | *[[olomoucine]] | ||
*[[ouabain]] | *[[ouabain]] | ||
*[[PD-407824]] | |||
*[[p-MPPI]] | *[[p-MPPI]] | ||
*[[taxol|Paclitaxel]] | |||
*[[phaclofen]] | *[[phaclofen]] | ||
*[[PMA]] | *[[PMA]] | ||
*[[ | *[[PP2]] | ||
*[[ | *[[primaquine]] | ||
*[[propylthiouracil]] | |||
*[[quinpirole]] | |||
*[[rapamycin]] | |||
*[[retinoic acid]] | *[[retinoic acid]] | ||
*[[RS67333]] | *[[RS67333]] | ||
*[[RU486]] | *[[RU486]] | ||
*[[SB 203580]] | *[[SB 203580]] | ||
*[[SCH28080]] | |||
*[[sodium nitroprusside]] | *[[sodium nitroprusside]] | ||
*[[SP600125 ]] | *[[SP600125 ]] | ||
*[[SU5402]] | *[[SU5402]] | ||
*[[SU6656]] | |||
*[[Suramin]] | *[[Suramin]] | ||
*[[tautomycin]] | |||
*[[taxol]] | |||
*[[thyroxine (T4)]] | *[[thyroxine (T4)]] | ||
*[[TTNPB]] | *[[TTNPB]] | ||
Line 64: | Line 91: | ||
*[[Y27632]] | *[[Y27632]] | ||
*[[ZM 447439]] | *[[ZM 447439]] | ||
The Following are in need of standardization and curation | |||
*[[AP1510]] | |||
*[[AR-A014418]] | |||
*[[BHQ]] | |||
*[[b-aminoproprionitrile]] | |||
*[[beclomethasone]] | |||
*[[Butyrate]] | |||
*[[celastrol]] | |||
*[[celecoxib]] | |||
*[[chromanol 293B]] | |||
*[[cytochalasin D]] | |||
*[[colchicine]] | |||
*[[diclofenac]] | |||
*[[etoposide]] | |||
*[[GW843682X]] | |||
*[[latrunculin B]] | |||
*[[methimazole]] | |||
*[[MBCD or MBetaCD]] | |||
*[[MS222]] | |||
*[[nicardipine]] | |||
*[[Nu6102]] | |||
*[[PTU|propylthiouracil(PTU) inhibits thyroxine]] | |||
*[[PTU|phenylthiouracil(PTU inhibits melanophore formation]] | |||
*[[purmorphamine]] | |||
*[[Pyrazoleanthrone]] | |||
*[[R(+)BayK 8644]] | |||
*[[RHC80267]] | |||
*[[RL-3]] | |||
*[[SB-431542]] | |||
*[[SB505124]] | |||
*[[TG003]] | |||
*[[Thapsigargin]] | |||
*[[Trichostain A]] | |||
*[[U0126]] | |||
*[[U73122]] | |||
*[[Echinomycin]] | |||
*[[Gö 6983]] | |||
*[[phenylhydrazine]] | |||
==List of Molecules Affecting Specific Pathways== | ==List of Molecules Affecting Specific Pathways== | ||
===cAMP=== | ===cAMP=== | ||
[[IBMX]] | *[[IBMX]] | ||
*[[RU486]] | |||
===CDK/Cyclins=== | |||
*[[olomoucine]] | |||
===ERK/MAPK=== | ===ERK/MAPK=== | ||
*[[U0126]] | |||
===JAK/STAT=== | ===JAK/STAT=== | ||
*[[AZD1480]] | *[[AZD1480]] | ||
===JNK=== | ===JNK=== | ||
[[SP600125]] | *[[SP600125]] | ||
*[[Pyrazoleanthrone]] | |||
===Nitric Oxide=== | |||
*[[sodium nitroprusside]] | |||
===PDGF=== | ===PDGF=== | ||
*[[AG1296]] | *[[AG1296]] | ||
*[[AP1510]] | |||
===Retinoic Acid=== | ===Retinoic Acid=== | ||
*[[AGN193109]] | *[[AGN193109]] | ||
*[[retinoic acid]] | *[[retinoic acid]] | ||
*[[TTNPB]] | *[[TTNPB]] | ||
*[[BMS-453]] | |||
===Shh=== | ===Shh=== | ||
*[[cyclopamine]] | *[[cyclopamine]] | ||
*[[ | *[[purmorphamine]] | ||
===TGF-beta/BMP=== | ===TGF-beta/BMP=== | ||
*[[SB-431542]] | |||
*[[SB505124]] | |||
===Thyroid Signaling=== | |||
*[[PTU]] | |||
===Wnt=== | ===Wnt=== | ||
*[[LiCl]] | *[[LiCl]] | ||
===Epigenetics=== | ===Epigenetics=== | ||
[[Ex-527]] | *[[Ex-527]] | ||
===Protease Inhibitors=== | ===Protease Inhibitors=== | ||
*[[chymostatin]] | *[[chymostatin]] | ||
*[[GM6001|GM6001 (MMP inhibitor)]] | *[[GM6001|GM6001 (MMP inhibitor)]] | ||
*[[o-phenanthroline|o-phenanthroline(MMP inhibitor)]] | *[[o-phenanthroline|o-phenanthroline(MMP inhibitor)]] | ||
*[[BB-94|BB-94 MMP inhibitor]] | |||
*[[GI254023X| GI254023X MMP10 inhibitor]] | |||
==Small Molecules by Biological Function== | |||
===Angiogenesis=== | |||
*[[herbimycin A]] | |||
*[[Suramin]] | |||
===Small Molecules | ===Apoptosis=== | ||
*[[cycloheximide]] | |||
*[[alpha-amanitin]] | |||
*[[Cyclosporin A]] | |||
*[[2,2ʹ-Methylenebis(1,3-cyclohexanedione)]] | |||
*[[NS3694]] | |||
===Autophagy=== | |||
*[[LY-294002]] | |||
===Calcium Signaling=== | |||
*[[nifedipine]] | |||
*[[R(+)BayK 8644]] | |||
*[[nicardipine]] | |||
*[[deltamethrin]] | |||
*[[BHQ]] | |||
*[[Thapsigargin]] | |||
===Circadian Rhythm=== | |||
*[[quinpirole]] | |||
===Cytoskeletal Inhibitors=== | |||
*[[Cytochalasin B]] | |||
*[[cytochalasin D]] | |||
*[[Colcemide]] | |||
*[[jasplakinolide]] is an activator | |||
*[[taxol]] | |||
*[[taxol|Paclitaxel]] | |||
===Cell Cycle, including mitosis=== | |||
*[[Colcemide]] | |||
*[[olomoucine]] | |||
*[[PD-407824]] | |||
===DNA Damage/Repair=== | |||
*[[etoposide]] | |||
===Growth Cone, Filopodia, and other Cytoskeletal projections=== | |||
*[[PP2]] | |||
*[[SU6656]] | |||
*[[cytochalasin D]] 0.1 uM Sigma | |||
*[[latrunculin B]] 30nM Sigma | |||
*[[colchicine]] 12.5uM Sigma | |||
*[[nocodazole]] 0.1uM Sigma | |||
*[[RHC80267]] | |||
===Hatching=== | |||
*[[ouabain]] | |||
===Metamorphosis=== | |||
*[[3,3,5-triiodothyronine (T3)]] | |||
*[[methimazole]] | |||
*[[propylthiouracil]] | |||
*[[thyroxine (T4)]] | |||
===Neurotransmission=== | |||
*[[diazepam]] | |||
*[[p-MPPI]] | |||
*[[phaclofen]] | |||
*[[RS67333]] | |||
*[[deltamethrin]] | |||
===Protein Recycling=== | |||
*[[primaquine]] | |||
==Drugs by Gene Class== | |||
===Channels, including ATPases=== | |||
*[[ouabain]] | |||
===G Protein Receptors=== | |||
*[[purmorphamine]] | |||
===Kinases=== | |||
*[[KT 5720]] | |||
*[[olomoucine]] | |||
*[[PD-407824]] | |||
*[[SB 203580]] | |||
*[[Y27632]] | |||
*[[ZM 447439]] | |||
===Phosphatases=== | |||
*[[Cyclosporin A]] | |||
*[[deltamethrin]] | |||
*[[okadaic acid]] | |||
*[[tautomycin]] | |||
===Small GTPases=== | |||
===Protein Synthesis=== | |||
*[[anisomycin]] 40uM Sigma | |||
*[[cycloheximide]] 40uM | |||
==Textpresso Small Molecules to Research== | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=43038 importazole inhibits importin] | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 M119] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 M119] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 GBG or GBetaGamma] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 GBG or GBetaGamma or G Protein Beta Gamma] | ||
*[[LY-294002| LY-294002 inhibits PI3K and autophagy]] | |||
==Models of Anemia== | |||
*[phenylhydrazine] |
Revision as of 12:56, 8 August 2016
Notice to our users
Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email.
Important small molecule references
- Database of Small Molecules by Feldman and Hogue 2006 at PubChem
- Wnt/Notch by Myers and Krieg 2014
- Ubiquitin-proteasome by Salic and King 2005
Alphabetical List of Small Molecules With Literature References
- 11-cis retinal
- 18alpha-glycyrretinic acid
- 3,3,5-triiodothyronine (T3)
- 5HT (seratonin)
- activin
- AG1296
- AG1879
- AGN193109
- alpha-amanitin
- anandamide
- apelin
- aphidicolin
- AZD1480
- BAPTA-AM
- BMS-453
- beta-xyloside
- bumetanide
- calcium ionophore
- CGP54626
- Chelerythrine
- chymostatin
- Colcemide
- concanamycin
- cycloheximide
- cyclopamine
- Cyclosporin A
- Cytochalasin B
- cytochalasin D
- Demecolcine
- deltamethrin
- dexamethosone
- DHT(dihydrotestosterone)
- diazepam
- Ex-527
- forskolin
- fusicoccin
- gentamycin
- GM6001
- heptanol
- herbimycin A
- IBMX
- jasplakinolide
- KT 5720
- lansoprazole
- LiCl
- Mg132
- MMP-2 inhibitor II
- nicorandil
- nifedipine
- nocodazole
- NSC-87877
- o-phenanthroline
- okadaic acid
- olomoucine
- ouabain
- PD-407824
- p-MPPI
- Paclitaxel
- phaclofen
- PMA
- PP2
- primaquine
- propylthiouracil
- quinpirole
- rapamycin
- retinoic acid
- RS67333
- RU486
- SB 203580
- SCH28080
- sodium nitroprusside
- SP600125
- SU5402
- SU6656
- Suramin
- tautomycin
- taxol
- thyroxine (T4)
- TTNPB
- tunicamycin
- Y27632
- ZM 447439
The Following are in need of standardization and curation
- AP1510
- AR-A014418
- BHQ
- b-aminoproprionitrile
- beclomethasone
- Butyrate
- celastrol
- celecoxib
- chromanol 293B
- cytochalasin D
- colchicine
- diclofenac
- etoposide
- GW843682X
- latrunculin B
- methimazole
- MBCD or MBetaCD
- MS222
- nicardipine
- Nu6102
- propylthiouracil(PTU) inhibits thyroxine
- phenylthiouracil(PTU inhibits melanophore formation
- purmorphamine
- Pyrazoleanthrone
- R(+)BayK 8644
- RHC80267
- RL-3
- SB-431542
- SB505124
- TG003
- Thapsigargin
- Trichostain A
- U0126
- U73122
- Echinomycin
- Gö 6983
- phenylhydrazine
List of Molecules Affecting Specific Pathways
cAMP
CDK/Cyclins
ERK/MAPK
JAK/STAT
JNK
Nitric Oxide
PDGF
Retinoic Acid
Shh
TGF-beta/BMP
Thyroid Signaling
Wnt
Epigenetics
Protease Inhibitors
- chymostatin
- GM6001 (MMP inhibitor)
- o-phenanthroline(MMP inhibitor)
- BB-94 MMP inhibitor
- GI254023X MMP10 inhibitor
Small Molecules by Biological Function
Angiogenesis
Apoptosis
Autophagy
Calcium Signaling
Circadian Rhythm
Cytoskeletal Inhibitors
- Cytochalasin B
- cytochalasin D
- Colcemide
- jasplakinolide is an activator
- taxol
- Paclitaxel
Cell Cycle, including mitosis
DNA Damage/Repair
Growth Cone, Filopodia, and other Cytoskeletal projections
- PP2
- SU6656
- cytochalasin D 0.1 uM Sigma
- latrunculin B 30nM Sigma
- colchicine 12.5uM Sigma
- nocodazole 0.1uM Sigma
- RHC80267
Hatching
Metamorphosis
Neurotransmission
Protein Recycling
Drugs by Gene Class
Channels, including ATPases
G Protein Receptors
Kinases
Phosphatases
Small GTPases
Protein Synthesis
- anisomycin 40uM Sigma
- cycloheximide 40uM
Textpresso Small Molecules to Research
- importazole inhibits importin
- M119
- GBG or GBetaGamma or G Protein Beta Gamma
- LY-294002 inhibits PI3K and autophagy
Models of Anemia
- [phenylhydrazine]