Small Molecules for Xenopus Research: Difference between revisions
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| Line 11: | Line 11: | ||
*[[1,3-Dicyclohexylurea]] | *[[1,3-Dicyclohexylurea]] | ||
*[[11-cis retinal]] | *[[11-cis retinal]] | ||
*[[18alpha- | *[[18alpha-glycyrrhetinic acid]] | ||
*[[2'-deoxyadenosine]] | |||
*[[2-APB]] | |||
*[[2-Deoxyglucose]] | |||
*[[3,3,5-triiodothyronine (T3)]] | *[[3,3,5-triiodothyronine (T3)]] | ||
*[[5HT (seratonin)]] | *[[5HT (seratonin)]] | ||
*[[8-Pcpt-2-O-Me-cAMP-AM]] | |||
*[[activin]] | *[[activin]] | ||
*[[Adenosine, periodate oxidized]] | |||
*[[AG1296]] | *[[AG1296]] | ||
*[[AG1879]] | *[[AG1879]] | ||
*[[AGN193109]] | *[[AGN193109]] | ||
*[[alpha-amanitin]] | *[[alpha-amanitin]] | ||
*[[Alisertib]] | |||
*[[anandamide]] | *[[anandamide]] | ||
*[[AP-III-a4]] | |||
*[[apelin]] | *[[apelin]] | ||
*[[aphidicolin]] | *[[aphidicolin]] | ||
*[[Aroclor 1254]] | |||
*[[Atrazine]] | |||
*[[AZD1480]] | *[[AZD1480]] | ||
*[[Bafilomycin A1]] | |||
*[[BAPTA-AM]] | *[[BAPTA-AM]] | ||
*[[Barasertib]] | |||
*[[Benzaldehyde, 3-allyl-2-(2-(diethylamino)ethoxy)-(DEAB)]] | |||
*[[beta-xyloside]] | |||
*[[blebbistatin]] | |||
*[[BMS-453]] | *[[BMS-453]] | ||
*[[ | *[[Brefeldin A (BFA)]] | ||
*[[bumetanide]] | *[[bumetanide]] | ||
*[[calcium ionophore]] | *[[calcium ionophore]] | ||
*[[canertinib]] | |||
*[[CGP54626 ]] | *[[CGP54626 ]] | ||
*[[Chelerythrine]] | *[[Chelerythrine]] | ||
*[[chenodeoxycholic acid]] | *[[chenodeoxycholic acid]] | ||
*[[chlorpromazine]] | |||
*[[chymostatin ]] | *[[chymostatin ]] | ||
*[[Citral]] | *[[Citral]] | ||
*[[Colcemide]] | *[[Colcemide]] | ||
*[[concanamycin]] | *[[concanamycin]] | ||
*[[CP-91149]] | |||
*[[cycloheximide]] | *[[cycloheximide]] | ||
*[[cyclopamine]] | *[[cyclopamine]] | ||
| Line 40: | Line 57: | ||
*[[Cytochalasin B]] | *[[Cytochalasin B]] | ||
*[[cytochalasin D]] | *[[cytochalasin D]] | ||
*[[ | *[[D-AP5]] | ||
*[[D-NAME]] | |||
*[[deltamethrin]] | *[[deltamethrin]] | ||
*[[dexamethosone]] | *[[dexamethosone]] | ||
| Line 46: | Line 64: | ||
*[[diazepam]] | *[[diazepam]] | ||
*[[Difopein]] | *[[Difopein]] | ||
*[[Diphenyleneiodonium Chloride]] | |||
*[[DMH-1]] | |||
*[[Dorsomorphin]] | *[[Dorsomorphin]] | ||
*[[DRB]] | |||
*[[Ex-527]] | *[[Ex-527]] | ||
*[[finasteride]] | *[[finasteride]] | ||
*[[folic acid]] | |||
*[[forskolin]] | *[[forskolin]] | ||
*[[fusicoccin]] | *[[fusicoccin]] | ||
*[[gallein]] | |||
*[[GANT 61]] | |||
*[[gentamycin]] | *[[gentamycin]] | ||
*[[GSK3-inhibitor IX (BIO)]] | |||
*[[GM6001]] | *[[GM6001]] | ||
*[[H-89 Dihydrochloride]] | |||
*[[heptanol]] | *[[heptanol]] | ||
*[[herbimycin A]] | *[[herbimycin A]] | ||
*[[Hh-Ag1.8]] | |||
*[[Hydroxyurea]] | *[[Hydroxyurea]] | ||
*[[IBMX]] | *[[IBMX]] | ||
*[[Iodoacetic acid]] | |||
*[[jasplakinolide]] | *[[jasplakinolide]] | ||
*[[6-B345TTQ]] | |||
*[[Ketamine]] | |||
*[[KT 5720]] | *[[KT 5720]] | ||
*[[L-NAME]] | |||
*[[lansoprazole]] | *[[lansoprazole]] | ||
*[[latrunculin A]] | |||
*[[latrunculin B]] | *[[latrunculin B]] | ||
*[[ | *[[LDN-193189]] | ||
*[[Leflunomide]] | |||
*[[leucovorin]] | |||
*[[LiCl]] | *[[LiCl]] | ||
*[[Lovastatin]] | |||
*[[LY294002]] | *[[LY294002]] | ||
*[[m-3M3FBS]] | |||
*[[methotrexate (MTX)]] | |||
*[[metronidazole]] | |||
*[[Mg132]] | *[[Mg132]] | ||
*[[MK-2206]] | |||
*[[MMP-2 inhibitor II]] | *[[MMP-2 inhibitor II]] | ||
*[[MS-275]] | |||
*[[Mubritinib]] | |||
*[[nicorandil]] | *[[nicorandil]] | ||
*[[Nicotinamide]] | *[[Nicotinamide]] | ||
*[[Nicotinic acid]] | |||
*[[nifedipine]] | *[[nifedipine]] | ||
*[[nocodazole]] | *[[nocodazole]] | ||
| Line 75: | Line 117: | ||
*[[olomoucine]] | *[[olomoucine]] | ||
*[[ouabain]] | *[[ouabain]] | ||
*[[Olygomycin]] | |||
*[[PD173074]] | |||
*[[PD-407824]] | *[[PD-407824]] | ||
*[[p-MPPI]] | *[[p-MPPI]] | ||
*[[taxol|Paclitaxel]] | *[[taxol|Paclitaxel]] | ||
*[[phaclofen]] | *[[phaclofen]] | ||
*[[phenylthiourea|phenylthiourea (PTU)]] | |||
*[[Picropodophyllin]] | *[[Picropodophyllin]] | ||
*[[PMA]] | *[[PMA]] | ||
*[[PP2]] | *[[PP2]] | ||
*[[primaquine]] | *[[primaquine]] | ||
*[[Progesterone]] | |||
*[[propylthiouracil]] | *[[propylthiouracil]] | ||
*[[psoralen]] | |||
*[[pyrimethamine]] | |||
*[[quinpirole]] | *[[quinpirole]] | ||
*[[rac1 inhibitor]] | |||
*[[rapamycin]] | *[[rapamycin]] | ||
*[[retinoic acid]] | *[[retinoic acid]] | ||
*[[Retinol]] | *[[Retinol]] | ||
*[[RO-3306]] | |||
*[[RS67333]] | *[[RS67333]] | ||
*[[RU486]] | *[[RU486]] | ||
*[[SAHA]] | |||
*[[SB 203580]] | *[[SB 203580]] | ||
*[[SB431542]] | |||
*[[SB-505124]] | |||
*[[SCH28080]] | *[[SCH28080]] | ||
*[[SNAP]] | |||
*[[sodium nitroprusside]] | *[[sodium nitroprusside]] | ||
*[[sodium perchlorate]] | |||
*[[SP600125 ]] | *[[SP600125 ]] | ||
*[[SU5402]] | *[[SU5402]] | ||
| Line 101: | Line 156: | ||
*[[thyroxine (T4)]] | *[[thyroxine (T4)]] | ||
*[[Torin 2]] | *[[Torin 2]] | ||
*[[Trichostatin A]] | |||
*[[trimetrexate]] | |||
*[[Triptolide]] | |||
*[[TTNPB]] | *[[TTNPB]] | ||
*[[Tubercidin]] | |||
*[[tunicamycin]] | *[[tunicamycin]] | ||
*[[Tyrphostin AG 1478]] | *[[Tyrphostin AG 1478]] | ||
*[[U73122]] | |||
*[[Y27632]] | *[[Y27632]] | ||
*[[ZM 447439]] | *[[ZM 447439]] | ||
| Line 116: | Line 176: | ||
*[[beclomethasone]] | *[[beclomethasone]] | ||
*[[Butyrate]] | *[[Butyrate]] | ||
*[[calcicludine]] | |||
*[[Calyculin A]] | *[[Calyculin A]] | ||
*[[celastrol]] | *[[celastrol]] | ||
| Line 126: | Line 187: | ||
*[[diclofenac]] | *[[diclofenac]] | ||
*[[etoposide]] | *[[etoposide]] | ||
*[[IWR1]] | |||
*[[GW843682X]] | *[[GW843682X]] | ||
*[[leptomycin B]] | *[[leptomycin B]] | ||
*[[LY320135]] | *[[LY320135]] | ||
*[[methylcellulose (MC)]] | *[[methylcellulose (MC)]] | ||
*[[methimazole]] | *[[methimazole]] | ||
| Line 136: | Line 197: | ||
*[[nicardipine]] | *[[nicardipine]] | ||
*[[Nu6102]] | *[[Nu6102]] | ||
*[[purmorphamine]] | *[[purmorphamine]] | ||
*[[Pyrazoleanthrone]] | *[[Pyrazoleanthrone]] | ||
| Line 143: | Line 202: | ||
*[[RHC80267]] | *[[RHC80267]] | ||
*[[RL-3]] | *[[RL-3]] | ||
*[[SAG]] | |||
*[[SB-431542]] | *[[SB-431542]] | ||
*[[TG003]] | *[[TG003]] | ||
*[[Thapsigargin]] | *[[Thapsigargin]] | ||
*[[U0126]] | *[[U0126]] | ||
*[[ursodeoxycholic acid]] | *[[ursodeoxycholic acid]] | ||
*[[valproic acid (VPA)]] | |||
*[[Echinomycin]] | *[[Echinomycin]] | ||
*[[Gö 6983]] | *[[Gö 6983]] | ||
*[[phenylhydrazine]] | *[[phenylhydrazine]] | ||
*[[ω-conotoxin–GVIA]] | |||
*[[flunarizine]] | |||
*[[tetrodotoxin]] | |||
*[[veratridine]] | |||
*[[NBI-27914]] | |||
==Small Molecules Affecting Pathways== | ==Small Molecules Affecting Pathways== | ||
| Line 162: | Line 225: | ||
===CDK/Cyclins=== | ===CDK/Cyclins=== | ||
*[[olomoucine]] | *[[olomoucine]] | ||
*[[RO-3306]] | |||
*[[R-roscovitine]] | |||
===ERK/MAPK=== | ===ERK/MAPK=== | ||
| Line 193: | Line 258: | ||
*[[cyclopamine]] | *[[cyclopamine]] | ||
*[[purmorphamine]] | *[[purmorphamine]] | ||
*[[Hh-Ag1.8]] | |||
*[[Vismodegib]] | |||
===TGF-beta/BMP=== | ===TGF-beta/BMP=== | ||
| Line 199: | Line 266: | ||
===Thyroid Signaling=== | ===Thyroid Signaling=== | ||
*[[ | *[[NH-3]] | ||
===Wnt=== | ===Wnt=== | ||
*[[LiCl]] | *[[LiCl]] | ||
*[[GSK3-inhibitor IX (BIO)]] | |||
*[[IWR1]] | |||
===Epigenetics=== | ===Epigenetics=== | ||
| Line 214: | Line 283: | ||
*[[GI254023X| GI254023X MMP10 inhibitor]] | *[[GI254023X| GI254023X MMP10 inhibitor]] | ||
==Small Molecules affecting | ==Small Molecules affecting Biological Functions & Processes== | ||
===Angiogenesis=== | ===Angiogenesis=== | ||
*[[dimethyloxallyl glycine (DMOG)]] | *[[dimethyloxallyl glycine (DMOG)]] | ||
| Line 245: | Line 314: | ||
*[[cytochalasin D]] | *[[cytochalasin D]] | ||
*[[Colcemide]] | *[[Colcemide]] | ||
*[[Colchicine]] | |||
*[[jasplakinolide]] is an activator | *[[jasplakinolide]] is an activator | ||
*[[latrunculin B]] | *[[latrunculin B]] | ||
| Line 255: | Line 325: | ||
*[[olomoucine]] | *[[olomoucine]] | ||
*[[PD-407824]] | *[[PD-407824]] | ||
===Cell migration, including specific cell lineage removal=== | |||
*[[Clodronate]] | |||
===Cilia=== | ===Cilia=== | ||
*[[methylcellulose (MC)]] | *[[methylcellulose (MC)]] | ||
| Line 264: | Line 337: | ||
===DNA Synthesis=== | ===DNA Synthesis=== | ||
*[[Calyculin A]] | *[[Calyculin A]] | ||
===DNA mutagenic compounds=== | |||
*[[ENU or N-nitroso-N-ethylurea]] 100mM Sigma N3385 | |||
===Growth Cone, Filopodia, and other Cytoskeletal projections=== | ===Growth Cone, Filopodia, and other Cytoskeletal projections=== | ||
| Line 303: | Line 380: | ||
*[[AM281]] | *[[AM281]] | ||
*[[LY320135]] | *[[LY320135]] | ||
*[[bafilomycin A1]] | |||
===G Protein Receptors=== | ===G Protein Receptors=== | ||
*[[purmorphamine]] | *[[purmorphamine]] | ||
| Line 326: | Line 405: | ||
*[[anisomycin]] 40uM Sigma | *[[anisomycin]] 40uM Sigma | ||
*[[cycloheximide]] 40uM | *[[cycloheximide]] 40uM | ||
===Retinoids=== | |||
*[[TTNPB]] Sigma | |||
==Textpresso Small Molecules to Research== | ==Textpresso Small Molecules to Research== | ||
| Line 334: | Line 416: | ||
==Models of Anemia== | ==Models of Anemia== | ||
*[ | *[[Phenylhydrazine]] | ||
==Environmental toxins== | |||
*[[Cis-bifenthrin (cis-BF)]] | |||
*[[Graphine (GO)]] | |||
*[[4-methylcyclohexane methanol (MCHM)]] | |||
*[[4-octylphenol (OP)]] | |||
*[[metamifop]] | |||
Latest revision as of 08:21, 16 May 2023
Notice to our users
Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email.
Important small molecule references
- Database of Small Molecules by Feldman and Hogue 2006 at PubChem
- Wnt/Notch by Myers and Krieg 2014
- Ubiquitin-proteasome by Salic and King 2005
Alphabetical List of Small Molecules With Literature References
- 1,3-Dicyclohexylurea
- 11-cis retinal
- 18alpha-glycyrrhetinic acid
- 2'-deoxyadenosine
- 2-APB
- 2-Deoxyglucose
- 3,3,5-triiodothyronine (T3)
- 5HT (seratonin)
- 8-Pcpt-2-O-Me-cAMP-AM
- activin
- Adenosine, periodate oxidized
- AG1296
- AG1879
- AGN193109
- alpha-amanitin
- Alisertib
- anandamide
- AP-III-a4
- apelin
- aphidicolin
- Aroclor 1254
- Atrazine
- AZD1480
- Bafilomycin A1
- BAPTA-AM
- Barasertib
- Benzaldehyde, 3-allyl-2-(2-(diethylamino)ethoxy)-(DEAB)
- beta-xyloside
- blebbistatin
- BMS-453
- Brefeldin A (BFA)
- bumetanide
- calcium ionophore
- canertinib
- CGP54626
- Chelerythrine
- chenodeoxycholic acid
- chlorpromazine
- chymostatin
- Citral
- Colcemide
- concanamycin
- CP-91149
- cycloheximide
- cyclopamine
- Cyclosporin A
- Cytochalasin B
- cytochalasin D
- D-AP5
- D-NAME
- deltamethrin
- dexamethosone
- DHT(dihydrotestosterone)
- diazepam
- Difopein
- Diphenyleneiodonium Chloride
- DMH-1
- Dorsomorphin
- DRB
- Ex-527
- finasteride
- folic acid
- forskolin
- fusicoccin
- gallein
- GANT 61
- gentamycin
- GSK3-inhibitor IX (BIO)
- GM6001
- H-89 Dihydrochloride
- heptanol
- herbimycin A
- Hh-Ag1.8
- Hydroxyurea
- IBMX
- Iodoacetic acid
- jasplakinolide
- 6-B345TTQ
- Ketamine
- KT 5720
- L-NAME
- lansoprazole
- latrunculin A
- latrunculin B
- LDN-193189
- Leflunomide
- leucovorin
- LiCl
- Lovastatin
- LY294002
- m-3M3FBS
- methotrexate (MTX)
- metronidazole
- Mg132
- MK-2206
- MMP-2 inhibitor II
- MS-275
- Mubritinib
- nicorandil
- Nicotinamide
- Nicotinic acid
- nifedipine
- nocodazole
- NSC-87877
- o-phenanthroline
- okadaic acid
- olomoucine
- ouabain
- Olygomycin
- PD173074
- PD-407824
- p-MPPI
- Paclitaxel
- phaclofen
- phenylthiourea (PTU)
- Picropodophyllin
- PMA
- PP2
- primaquine
- Progesterone
- propylthiouracil
- psoralen
- pyrimethamine
- quinpirole
- rac1 inhibitor
- rapamycin
- retinoic acid
- Retinol
- RO-3306
- RS67333
- RU486
- SAHA
- SB 203580
- SB431542
- SB-505124
- SCH28080
- SNAP
- sodium nitroprusside
- sodium perchlorate
- SP600125
- SU5402
- SU6656
- Suramin
- tautomycin
- taxol
- thyroxine (T4)
- Torin 2
- Trichostatin A
- trimetrexate
- Triptolide
- TTNPB
- Tubercidin
- tunicamycin
- Tyrphostin AG 1478
- U73122
- Y27632
- ZM 447439
The Following are in need of standardization and curation
- AM251
- AM281
- AP1510
- AR-A014418
- BHQ
- b-aminoproprionitrile
- beclomethasone
- Butyrate
- calcicludine
- Calyculin A
- celastrol
- celecoxib
- chromanol 293B
- chlorate
- cytochalasin D
- colchicine
- dimethyloxallyl glycine (DMOG)
- diclofenac
- etoposide
- IWR1
- GW843682X
- leptomycin B
- LY320135
- methylcellulose (MC)
- methimazole
- MBCD or MBetaCD
- MS222
- nicardipine
- Nu6102
- purmorphamine
- Pyrazoleanthrone
- R(+)BayK 8644
- RHC80267
- RL-3
- SAG
- SB-431542
- TG003
- Thapsigargin
- U0126
- ursodeoxycholic acid
- valproic acid (VPA)
- Echinomycin
- Gö 6983
- phenylhydrazine
- ω-conotoxin–GVIA
- flunarizine
- tetrodotoxin
- veratridine
- NBI-27914
Small Molecules Affecting Pathways
cAMP
CDK/Cyclins
ERK/MAPK
Folic Acid
JAK/STAT
JNK
Nitric Oxide
PDGF
Retinoic Acid
Shh
TGF-beta/BMP
Thyroid Signaling
Wnt
Epigenetics
Protease Inhibitors
- chymostatin
- GM6001 (MMP inhibitor)
- o-phenanthroline(MMP inhibitor)
- BB-94 MMP inhibitor
- GI254023X MMP10 inhibitor
Small Molecules affecting Biological Functions & Processes
Angiogenesis
Apoptosis
Autophagy
Calcium Signaling
Circadian Rhythm
Cytoskeletal Inhibitors
- Cytochalasin B
- cytochalasin D
- Colcemide
- Colchicine
- jasplakinolide is an activator
- latrunculin B
- taxol
- Paclitaxel
Cell Cycle, including mitosis
Cell migration, including specific cell lineage removal
Cilia
DNA Damage/Repair
DNA Synthesis
DNA mutagenic compounds
- ENU or N-nitroso-N-ethylurea 100mM Sigma N3385
Growth Cone, Filopodia, and other Cytoskeletal projections
- PP2
- SU6656
- cytochalasin D 0.1 uM Sigma
- latrunculin B 30nM Sigma
- colchicine 12.5uM Sigma
- nocodazole 0.1uM Sigma
- RHC80267
Hatching
Left-Right Patterning
Metamorphosis
Neurotransmission
Protein Recycling
Drugs by Gene Class
Channels, including ATPases
G Protein Receptors
Kinases
Phosphatases
Small GTPases
Protein Synthesis
- anisomycin 40uM Sigma
- cycloheximide 40uM
Retinoids
- TTNPB Sigma
Textpresso Small Molecules to Research
- importazole inhibits importin
- M119
- GBG or GBetaGamma or G Protein Beta Gamma
- LY-294002 inhibits PI3K and autophagy