AZD1480: Difference between revisions

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==Description==
==Description==
Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
[[File:azd1480.gif]]
[[File:azd1480.gif|frame|right|Structure of AZD1479, photo from Selleck Chemical]]


**Genes Affected
**Genes Affected

Revision as of 10:59, 28 May 2015

Description

Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.

Structure of AZD1479, photo from Selleck Chemical

Suppliers

Usage Notes

References