Psoralen: Difference between revisions
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imported>Xenbase (Created page with "==Description== "Psoralen is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity l...") |
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[[File:Screen Shot | [[File:Screen Shot 2019-09-04 at 12.06.18 PM.png|frame|right| structure, image from PubChem]] | ||
==Alternative names== | ==Alternative names== | ||
Latest revision as of 10:07, 4 September 2019
Description
"Psoralen is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids." Source: NCIt
Alternative names
- Ficusin
- 7H-Furo[3,2-g]chromen-7-one
- Furocoumarin
Usage Notes
References
> 97 Xenbase articles contain a reference to Psoralen according to textpresso