Chymostatin: Difference between revisions
imported>Kevin No edit summary |
imported>Kevin No edit summary |
||
| Line 10: | Line 10: | ||
*[http://www.emdmillipore.com/US/en/product/,EMD_BIO-230790?cid=BI-XX-BRC-P-GOOG-INHI-B319-1843 EMD Millipore] | *[http://www.emdmillipore.com/US/en/product/,EMD_BIO-230790?cid=BI-XX-BRC-P-GOOG-INHI-B319-1843 EMD Millipore] | ||
*[http://www.sigmaaldrich.com/catalog/product/sigma/c7268?lang=en®ion=US&gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlz7FHeu3zYRwTviYLLFnKY-PDaO2c6xNTFo7AIWOv3xoC4kvw_wcB Sigma] | *[http://www.sigmaaldrich.com/catalog/product/sigma/c7268?lang=en®ion=US&gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlz7FHeu3zYRwTviYLLFnKY-PDaO2c6xNTFo7AIWOv3xoC4kvw_wcB Sigma] | ||
**Genes Affected | |||
**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5953470 stsg] | |||
==Usage Notes== | ==Usage Notes== | ||
Revision as of 12:07, 28 May 2015
Description
"Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production."
- -Santa Cruz product description
Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)
Suppliers
- Cayman
- Santa Cruz
- EMD Millipore
- Sigma
- Genes Affected
- stsg
Usage Notes
References
>464 Xenbase articles contain a reference to chymostatin according to textpresso