IBMX and SCH28080: Difference between pages

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imported>Kevin
(Created page with "==Description== Phosphodiesterase inhibitor. "Biochem/physiol Actions Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of p...")
 
imported>Mfisher
 
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==Description==
==Description==
Phosphodiesterase inhibitor.
SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase.
 
*-Sigma product description
"Biochem/physiol Actions
[[File:Sch-28080.structure.png|frame|right|SCH-28080 structure, image from Pubchem]]
 
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons."
*-Sigma Product Description
[[File:IBMX.png|frame|right|IBMX structure, photo from Sigma-Aldrich]]


==Genes Affected==
==Genes Affected==


==Suppliers==
==Suppliers==
*[http://www.tocris.com/dispprod.php?ItemId=5345#.VWx399JVhBc Tocris 2845]
*[http://www.sigmaaldrich.com/catalog/product/sigma/s4443 Sigma Aldrich]
*[https://www.caymanchem.com/app/template/Product.vm/catalog/13347 Cayman 13347]
*[http://www.scbt.com/datasheet-201188-ibmx.html Santa Cruz sc-201188]
*[http://www.enzolifesciences.com/BML-PD140/ibmx/ Enzo]
*[https://www.lifetechnologies.com/order/catalog/product/PHZ1124 Life Technologies PHZ1124]
*[http://www.abcam.com/ibmx-ab120840.html Abcam ab120840]
*[http://www.sigmaaldrich.com/catalog/product/sigma/i5879?lang=en&region=US Sigma-Aldrich i5879]


==Usage Notes==
==Usage Notes==
1mM


==References==
==References==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=11986 Kim et al., 1999]
*[https://pubchem.ncbi.nlm.nih.gov/compound/Sch-28080 PubChem]
 
29 Xenbase articles contain a reference to SCH-28080 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]


>452 Xenbase articles contain a reference to IMBX according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
*
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]

Latest revision as of 08:52, 2 August 2016

Description

SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase.

  • -Sigma product description
SCH-28080 structure, image from Pubchem

Genes Affected

Suppliers

Usage Notes

References

29 Xenbase articles contain a reference to SCH-28080 according to textpresso

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