PP2 and Citral: Difference between pages

From XenWiki
(Difference between pages)
Jump to navigation Jump to search
imported>Kevin
No edit summary
 
imported>Mfisher
(Created page with "==Description== Inhibitor of aldh1a2 activity. frame|right|Citral structure, image from NCBI Pubchem ==Alternative Name== GERANIAL ==Chemical N...")
 
Line 1: Line 1:
==Description==
==Description==
Synonym: 4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, AG 1879
Inhibitor of aldh1a2 activity.
 
[[File:Citral.structure.png|frame|right|Citral structure, image from NCBI Pubchem]]  
"PP2 is a selective inhibitor of Src-family tyrosine kinases with >10,000-fold selectivity over ZAP-70 and JAK2."
==Alternative Name==  
*-Sigma Product Description
GERANIAL
 
==Chemical Name==
[[File:PP2.png|frame|right|PP2 structure, photo from Sigma-Aldrich]]
(2E)-3,7-dimethylocta-2,6-dienal
 
==Genes Affected==
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=489819 src]
 
==Suppliers==
==Suppliers==
*[http://www.emdmillipore.com/US/en/product/PP2---CAS-172889-27-9---Calbiochem,EMD_BIO-529573?bd=1 Calbiochem is now EMD Millipore]
[https://www.tocris.com/dispprod.php?ItemId=222005#.V2xIRfkrKM8 Tocris]
*[http://www.sigmaaldrich.com/catalog/product/sigma/p0042?lang=en&region=US Sigma]
 
==Usage Notes==
1uM in cell culture media, up to 10mM in certain applications
 
==References==
==References==
*[https://pubchem.ncbi.nlm.nih.gov/compound/4878 PubChem]
*[http://www.xenbase.org/literature/article.do?articleId=44961&method=display| ''Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.'' Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=1490 Robles et al., 2005]
*National Center for Biotechnology Information. PubChem Compound Database; CID=638011, [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=638011]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=9003 Browaeys-Poly et al. 2001]
 
>18 Xenbase articles contain a reference to PP2 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
*
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]

Revision as of 14:49, 8 August 2016

Description

Inhibitor of aldh1a2 activity.

Citral structure, image from NCBI Pubchem

Alternative Name

GERANIAL

Chemical Name

(2E)-3,7-dimethylocta-2,6-dienal

Suppliers

Tocris

References