NSC-87877: Difference between revisions
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==Description== | ==Description== | ||
"Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation." | |||
*-Tocris Product Description | |||
[[File:NSC-87877.png|frame|right|NSC-87877 structure, photo from Sigma-Aldrich]] | [[File:NSC-87877.png|frame|right|NSC-87877 structure, photo from Sigma-Aldrich]] | ||
==Genes Affected== | ==Genes Affected== | ||
SHP1/2 | SHP1/2 are synonyms for [http://www.xenbase.org/gene/showgene.do?method=display&geneId=487862& ptpn6] and [http://www.xenbase.org/gene/showgene.do?method=display&geneId=6054494 ptpn11] | ||
==Suppliers== | ==Suppliers== | ||
Revision as of 13:25, 23 June 2015
Description
"Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation."
- -Tocris Product Description
Genes Affected
SHP1/2 are synonyms for ptpn6 and ptpn11
Suppliers
Usage Notes
References
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