Ex-527: Difference between revisions

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imported>Kevin
(Created page with "==Description== "EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) fo...")
 
imported>Kevin
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*[http://www.sigmaaldrich.com/catalog/product/sigma/e7034?lang=en&region=US Sigma e7034]
*[http://www.sigmaaldrich.com/catalog/product/sigma/e7034?lang=en&region=US Sigma e7034]
*[http://www.selleckchem.com/products/EX-527.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlkmCpwJ2CFoS79fcsGxIJC8wm4FlXMKAzU8yN1-KfkRoCjSjw_wcB Selleck S1541]
*[http://www.selleckchem.com/products/EX-527.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlkmCpwJ2CFoS79fcsGxIJC8wm4FlXMKAzU8yN1-KfkRoCjSjw_wcB Selleck S1541]
*[http://www.abcam.com/EX-527-ab141506.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvldL9GZDZxp1g2z0yx0KZie-axeE-blvueltbr35eIzBoChtrw_wcB Abcam ab141506
*[http://www.abcam.com/EX-527-ab141506.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvldL9GZDZxp1g2z0yx0KZie-axeE-blvueltbr35eIzBoChtrw_wcB Abcam ab141506]
*[http://reactionbiology-com.3dcartstores.com/EX-527_p_329.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlwg7xuMkGe18trwHcvww-MMxwAFuhSm-pcMzwi_LESBoCqVHw_wcB Reaction EI-SRT-006]
*[http://reactionbiology-com.3dcartstores.com/EX-527_p_329.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlwg7xuMkGe18trwHcvww-MMxwAFuhSm-pcMzwi_LESBoCqVHw_wcB Reaction EI-SRT-006]
*[http://www.tocris.com/dispprod.php?ItemId=85010#.VWd_b9LBzRY Tocris 2780]
*[http://www.tocris.com/dispprod.php?ItemId=85010#.VWd_b9LBzRY Tocris 2780]


==Usage Notes==
==Usage Notes==

Revision as of 15:04, 28 May 2015

Description

"EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive."

    • -Sigma Description
Ex-527 structure, photo from Sigma-Aldrich

Genes Affected

Suppliers

Usage Notes

References

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