RS67333 and RU486: Difference between pages

Latest revision as of 07:35, 5 June 2018

Description

Synonym: Mifepristone "Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME."

-Pubchem Description

Genes Affected

creb1

Suppliers

Sigma

Usage Notes

References

>43 Xenbase articles contain a reference to RU486 according to textpresso

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 ==Description==
-A serotonergic
+Synonym: Mifepristone
+"Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME."
+*-Pubchem Description
-"A potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Active in vivo, with an intrinsic activity relative to 5-HT of 0.5."
+[[File:RU486.png|frame|right|RU486 structure, photo from pubchem]]
-*-Tocris Product Description
-[[File:RS_67333.png|frame|right|RS 67333 structure, photo from pubchem]]
 ==Genes Affected==
+*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=945014 creb1]
 ==Suppliers==
-*[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENBASE]
+*[http://www.sigmaaldrich.com/catalog/product/sigma/m8046?lang=en&region=US Sigma]
-*[http://www.tocris.com/dispprod.php?ItemId=2311#.VY2JyxtVhBc Tocris]
-*[Sigma]
 ==Usage Notes==
 ==References==
-*[https://pubchem.ncbi.nlm.nih.gov/compound/9800491 Pubchem]
+*[https://pubchem.ncbi.nlm.nih.gov/compound/55245 Pubchem]
-*[http://www.xenbase.org/literature/article.do?method=display&articleId=6115 Cheng et al., 2002]
+*[http://www.xenbase.org/literature/article.do?method=display&articleId=12136 Lutz et al., 1999]
+*[http://www.xenbase.org/literature/article.do?method=display&articleId=44538 Schreiber 2011]
-Search for additional Xenbase articles containing a reference to RS67333 with [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
+>43 Xenbase articles contain a reference to RU486 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
 *
 *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]