Difference between revisions of "XB-FEAT-22172617"
(Created page with "=nomenclature updates= 12.31.2019 This genepage was created after a review by David Webb from the NCBI and Xenbase curators. A synteny analysis of ''ripk3'' genes identif...")
Revision as of 17:53, 13 January 2020
This genepage was created after a review by David Webb from the NCBI and Xenbase curators.
A synteny analysis of ripk3 genes identified this gene ( Entrez gene ID: 100497374) as the Xenopus tropicalis ortholgue of human RIPK3 as its location and gene order is conserved across taxa.
In humans, frog, lizard and turtles, it is found in this gene order: nfatc4> ripk3> adcy4>.
In Xenopus tropicalis and X. laevis, ripk3 is on Chromosome 1, and chromsome 1.L respectively.
The 2 other ripk3 genes from earlier genome builds are not the true ortholgues of human RIPK3, and have been renamed as like genes.
In X. tropicalis, ripk3-like gene 1 is on currently placed on Chr2, and in X. Laevis, ripk3-like gene 1.L it is on Chromosome 8.L, although this needs more study to determine for sure.
Currently, there is no model for ripk3l.2.S ( watch this space!)
It seems that the ripk3l.1 and ripk3l.2 genes do not occur in other vertebrates except the caecillian (Rhinatrema bivittatum), and may represent an amphibian-specific gene duplication event.