Difference between revisions of "XB-FEAT-22172617"

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(Created page with "=nomenclature updates= 12.31.2019 This genepage was created after a review by David Webb from the NCBI and Xenbase curators. A synteny analysis of ''ripk3'' genes identif...")
 
(nomenclature updates)
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12.31.2019
 
12.31.2019
  
This genepage was created after a review by David Webb from the NCBI and Xenbase curators.  
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This gene page was created after a review by David Webb from the NCBI and Xenbase curators.  
  
A  synteny analysis of ''ripk3'' genes identified this gene ( Entrez gene ID: 100497374) as the Xenopus tropicalis ortholgue of human RIPK3 as its location and gene order is conserved across taxa.  
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A  synteny analysis of ''ripk3'' genes identified this gene ( Entrez gene ID: 100497374) as the Xenopus tropicalis orthologue of human RIPK3 as its location and gene order is conserved across taxa.  
  
 
In humans, frog, lizard and turtles, it is found in this gene order:  ''nfatc4''> ''ripk3''> ''adcy4''>.
 
In humans, frog, lizard and turtles, it is found in this gene order:  ''nfatc4''> ''ripk3''> ''adcy4''>.
  
In ''Xenopus tropicalis''  and ''X. laevis'', ripk3 is on Chromosome 1, and chromsome 1.L respectively.  
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In ''Xenopus tropicalis''  and ''X. laevis'', ripk3 is on Chromosome 1, and chromosome 1.L respectively.  
  
  
The 2 other ''ripk3'' genes from earlier genome builds are not the true ortholgues of human RIPK3, and have been renamed as ''like'' genes.
+
The 2 other ''ripk3'' genes from earlier genome builds are not the true orthologues of human RIPK3, and have been renamed as ''like'' genes.
  
 
In ''X. tropicalis'', '''ripk3-like gene 1''' is on currently placed on Chr2, and in X. Laevis, '''ripk3-like gene 1.L''' it is on Chromosome 8.L, although this needs more study to determine for sure.  
 
In ''X. tropicalis'', '''ripk3-like gene 1''' is on currently placed on Chr2, and in X. Laevis, '''ripk3-like gene 1.L''' it is on Chromosome 8.L, although this needs more study to determine for sure.  

Revision as of 17:54, 13 January 2020

nomenclature updates

12.31.2019

This gene page was created after a review by David Webb from the NCBI and Xenbase curators.

A synteny analysis of ripk3 genes identified this gene ( Entrez gene ID: 100497374) as the Xenopus tropicalis orthologue of human RIPK3 as its location and gene order is conserved across taxa.

In humans, frog, lizard and turtles, it is found in this gene order: nfatc4> ripk3> adcy4>.

In Xenopus tropicalis and X. laevis, ripk3 is on Chromosome 1, and chromosome 1.L respectively.


The 2 other ripk3 genes from earlier genome builds are not the true orthologues of human RIPK3, and have been renamed as like genes.

In X. tropicalis, ripk3-like gene 1 is on currently placed on Chr2, and in X. Laevis, ripk3-like gene 1.L it is on Chromosome 8.L, although this needs more study to determine for sure.

Currently, there is no model for ripk3l.2.S ( watch this space!)

It seems that the ripk3l.1 and ripk3l.2 genes do not occur in other vertebrates except the caecillian (Rhinatrema bivittatum), and may represent an amphibian-specific gene duplication event.