XB-FEAT-29084766

protein

uncharacterized protein LOC101730711 [Xenopus tropicalis]

NCBI Reference Sequence: XP_017952313.2

>XP_017952313.2 uncharacterized protein LOC101730711 [Xenopus tropicalis] MCHILIFILLFLFLFQRKICEGRGRLSCPAVMGPARLHPFIILLGLFHLFLSSTSAVKVENFTLFEEKLK LEAHTANMIPCVFHTRRRLNPLRVQLEWGKMDKEGYVPLIHLDGNHVRKAAADFGDKYQLFIPQVSQGNC SLVINPMDIADSGTYQVRLRILGKLYEPVPSIEIQVVDQRKVESRAWGKKKTTVPPTTIATVPPGFVDDV QKRLVKIDKMAIIAIILNGVFVGIAILLGVLVFITYRKKSSSGDEENPPKKRKQKGKKEPSDESEESSSS ESEESSSES

homology group analysis via EggNOGG v5

11DEC2023 LOC101730711 is an uncharacterized protein coding gene on Xtr.chr8, sitting among a cluster of similarly uncharacterized genes with LOC##### symbols.

Species	Chromosome	< 5	< 4	< 3	< 2	< 1	Gene of Interest	> 1	> 2	> 3	> 4	> 5
X.tropicalis	chr8	cfap45	nlrp4	LOC116406898	LOC116406897	LOC100486737	GeneID:101730711;LOC101730711;	LOC100488807	LOC100488643	LOC101730590	LOC116406952	LOC100491706

The protein sequence of this uncharacterized protein matches 434 proteins in 96 species with high confidence, most of which are named amica1

the protein has 1 or more Immunoglobulin V-set domain(s) and has assigned monocyte extravasation as a major molecular function.

Should this LOC# be called amica1?

synteny

11DEC2023 Strangely, NCBI has the X.trop mpzl3 gene listed as an orthology of human JAML, even though the structure/architecture of this protein is completely different, but it is very close to in in the syntenic pattern- see table below (using mpzl2 as anchor).

Species	Chromosome	< 5	< 4	< 3	< 2	< 1	Gene of Interest	> 1	> 2	> 3	> 4	> 5
X.tropicalis	chr7	atp5mg	ube4a	LOC116412324	cd3g	cd3e	GeneID:549209;mpzl2;	mpzl3	scn2b	scn4b	tmprss4	smim35
X.laevis	chr7L	vps11.L	kmt2a.L	atp5mg.L	ube4a.L	cd3e.L	GeneID:446705;mpzl2.L;	mpzl3.L	scn2b.L	LOC121395544	scn4b.L	tmprss4.L
H.sapiens	Chr11	scn4b	scn2b	JAML	HSPE1P18	mpzl3	GeneID:10205; MPZL2	cd3e	CD3D	cd3g	ube4a	LOC100131626
M.musculus	chr9	ube4a	Gm19121	cd3g	CD3D	cd3e	GeneID:14012; Mpzl2	mpzl3	JAML	Gm10684	scn2b	scn4b