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| ==Description== | | ==Description== |
| Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.
| | Inhibits heart looping |
| [[File:BAPTAAM.png|frame|right|Structure of BAPTA-AM, photo from Sigma-Aldrich]]
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| **Genes Affected
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| **[http://www.xenbase.org/gene/showgene.do?method=display&geneId=983103 kcnh2]
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| **[http://www.xenbase.org/gene/showgene.do?method=display&geneId=6037400 kcna5]
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| **[http://www.xenbase.org/gene/showgene.do?method=display&geneId=991577 kcna3]
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| ==Suppliers== | | ==Suppliers== |
| *[https://www.lifetechnologies.com/order/catalog/product/B1205 Life Technologies B1205]
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| *[http://www.sigmaaldrich.com/catalog/product/sigma/a1076?lang=en®ion=US Sigma A1076]
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| *[http://www.tocris.com/dispprod.php?ItemId=5296#.VWcXP9LBzRY Tocris 2787]
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| *[http://www.scbt.com/datasheet-202488-bapta-am.html Santa Cruz sc-202488]
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| ==Usage Notes== | | ==Usage Notes== |
| .4uM in .1x NAM
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| ==References== | | ==References== |
| *[https://pubchem.ncbi.nlm.nih.gov/compound/2293 PubChem]
| | *[http://www.xenbase.org/literature/article.do?method=display&articleId=25491 Yost 1990 ] |
| *[http://www.xenbase.org/literature/article.do?method=display&articleId=4661 Leclerc et al., 2003] | |
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| >762 Xenbase articles contain a reference to BAPTA-AM according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
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| *
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| *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]
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Revision as of 07:49, 28 May 2015
Description
Inhibits heart looping
Suppliers
Usage Notes
References