XB-FEAT-22041727

dact4

This is the community wiki page for the gene dact4 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

name changed from XB22041727 to dact4 following description of this new gene and its phylogentic relationships in eth dapper family of genes by Gabriele Colozza and Eddy De Robertis, see Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins, Gene Expression Patterns, 2020. [1]

summary from NCBI for human DACT family genes

The protein [family] encoded by thiesegene belong to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. They interacts with, and positively regulate dishevelled-mediated signaling pathways during development. Depletion of DACT1 mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.

Note that Xenopus dact4 does not to have a human ortholog.