XB-FEAT-489247: Difference between revisions
imported>Xenbase gene generator No edit summary |
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=nedd4l= | =nedd4l= | ||
This is the community wiki page for the gene ''nedd4l'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''nedd4l'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=nomenclature changes= | |||
05.13.19 | |||
Human name has changed for Entrez Gene: 23327. From neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | |||
to NEDD4 like E3 ubiquitin protein ligase | |||
= Summary from NCBI for human NEDD4L= | |||
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] | |||
Revision as of 09:02, 14 May 2019
nedd4l
This is the community wiki page for the gene nedd4l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
05.13.19
Human name has changed for Entrez Gene: 23327. From neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
to NEDD4 like E3 ubiquitin protein ligase
Summary from NCBI for human NEDD4L
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]