Small Molecules for Xenopus Research and BAPTA-AM: Difference between pages

From XenWiki
(Difference between pages)
Jump to navigation Jump to search
imported>Xenbase
 
imported>Kevin
(Created page with "==Description== Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1...")
 
Line 1: Line 1:
==Notice to our users==
==Description==
Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email.
Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.
[[File:BAPTAAM.png]]


==Important small molecule references==
**Genes Affected
*[http://www.xenbase.org/literature/article.do?method=display&articleId=35021 Database of Small Molecules by Feldman and Hogue 2006] at [https://pubchem.ncbi.nlm.nih.gov/ PubChem]
**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=983103 kcnh2]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=47903 Wnt/Notch by Myers and Krieg 2014]
**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=6037400 kcna5]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=970 Ubiquitin-proteasome by Salic and King 2005]
**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=991577 kcna3]


==Alphabetical List of Small Molecules With Literature References==
==Suppliers==
*[https://www.lifetechnologies.com/order/catalog/product/B1205 Life Technologies B1205]
*[http://www.sigmaaldrich.com/catalog/product/sigma/a1076?lang=en&region=US Sigma A1076]
*[http://www.tocris.com/dispprod.php?ItemId=5296#.VWcXP9LBzRY Tocris 2787]
*[http://www.scbt.com/datasheet-202488-bapta-am.html Santa Cruz sc-202488]


*[[1,3-Dicyclohexylurea]]
==Usage Notes==
*[[11-cis retinal]]
.4uM in .1x NAM
*[[18alpha-glycyrretinic acid]]
*[[2'-deoxyadenosine]]
*[[2-APB]]
*[[2-Deoxyglucose]]
*[[3,3,5-triiodothyronine (T3)]]
*[[5HT (seratonin)]]
*[[8-Pcpt-2-O-Me-cAMP-AM]]
*[[activin]]
*[[AG1296]]
*[[AG1879]]
*[[AGN193109]]
*[[alpha-amanitin]]
*[[anandamide]]
*[[AP-III-a4]]
*[[apelin]]
*[[aphidicolin]]
*[[AZD1480]]
*[[Bafilomycin A1]]
*[[BAPTA-AM]]
*[[Barasertib]]
*[[Benzaldehyde, 3-allyl-2-(2-(diethylamino)ethoxy)-(DEAB)]]
*[[beta-xyloside]]
*[[blebbistatin]]
*[[BMS-453]]
*[[Brefeldin A (BFA)]]
*[[bumetanide]]
*[[calcium ionophore]]
*[[CGP54626 ]]
*[[Chelerythrine]]
*[[chenodeoxycholic acid]]
*[[chymostatin ]]
*[[Citral]]
*[[Colcemide]]
*[[concanamycin]]
*[[CP-91149]]
*[[cycloheximide]]
*[[cyclopamine]]
*[[Cyclosporin A]]
*[[Cytochalasin B]]
*[[cytochalasin D]]
*[[D-AP5]]
*[[D-NAME]]
*[[Colcemide|Demecolcine]]
*[[deltamethrin]]
*[[dexamethosone]]
*[[DHT(dihydrotestosterone)]]
*[[diazepam]]
*[[Difopein]]
*[[Diphenyleneiodonium Chloride]]
*[[DMH-1]]
*[[Dorsomorphin]]
*[[DRB]]
*[[Ex-527]]
*[[finasteride]]
*[[folic acid]]
*[[forskolin]]
*[[fusicoccin]]
*[[gallein]]
*[[GANT 61]]
*[[gentamycin]]
*[[GSK3-inhibitor IX (BIO)]]
*[[GM6001]]
*[[H-89 Dihydrochloride]]
*[[heptanol]]
*[[herbimycin A]]
*[[Hydroxyurea]]
*[[IBMX]]
*[[Iodoacetic acid]]
*[[jasplakinolide]]
*[[6-B345TTQ]]
*[[KT 5720]]
*[[L-NAME]]
*[[lansoprazole]]
*[[latrunculin A]]
*[[latrunculin B]]
*[[LDN-193189]]
*[[leucovorin]]
*[[LiCl]]
*[[LY294002]]
*[[m-3M3FBS]]
*[[methotrexate (MTX)]]
*[[metronidazole]]
*[[Mg132]]
*[[MK-2206]]
*[[MMP-2 inhibitor II]]
*[[MS-275]]
*[[nicorandil]]
*[[Nicotinamide]]
*[[Nicotinic acid]]
*[[nifedipine]]
*[[nocodazole]]
*[[NSC-87877]]
*[[o-phenanthroline]]
*[[okadaic acid]]
*[[olomoucine]]
*[[ouabain]]
*[[Olygomycin]]
*[[PD173074]]
*[[PD-407824]]
*[[p-MPPI]]
*[[taxol|Paclitaxel]]
*[[phaclofen]]
*[[Picropodophyllin]]
*[[PMA]]
*[[PP2]]
*[[primaquine]]
*[[Progesterone]]
*[[propylthiouracil]]
*[[pyrimethamine]]
*[[quinpirole]]
*[[rac1 inhibitor]]
*[[rapamycin]]
*[[retinoic acid]]
*[[Retinol]]
*[[RO-3306]]
*[[RS67333]]
*[[RU486]]
*[[SAHA]]
*[[SB 203580]]
*[[SB431542]]
*[[SB 505124]]
*[[SCH28080]]
*[[SNAP]]
*[[sodium nitroprusside]]
*[[SP600125 ]]
*[[SU5402]]
*[[SU6656]]
*[[Suramin]]
*[[tautomycin]]
*[[taxol]]
*[[thyroxine (T4)]]
*[[Torin 2]]
*[[Trichostatin A]]
*[[trimetrexate]]
*[[Triptolide]]
*[[TTNPB]]
*[[Tubercidin]]
*[[tunicamycin]]
*[[Tyrphostin AG 1478]]
*[[U73122]]
*[[Y27632]]
*[[ZM 447439]]


The Following are in need of standardization and curation
==References==
*[[AM251]]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=4661 Leclerc et al., 2003]
*[[AM281]]
*[[AP1510]]
*[[AR-A014418]]
*[[BHQ]]
*[[b-aminoproprionitrile]]
*[[beclomethasone]]
*[[Butyrate]]
*[[calcicludine]]
*[[Calyculin A]]
*[[celastrol]]
*[[celecoxib]]
*[[chromanol 293B]]
*[[chlorate]]
*[[cytochalasin D]]
*[[colchicine]]
*[[dimethyloxallyl glycine (DMOG)]]
*[[diclofenac]]
*[[etoposide]]
*[[IWR1]]
*[[GW843682X]]
*[[leptomycin B]]
*[[LY320135]]
*[[methylcellulose (MC)]]
*[[methimazole]]
*[[MBCD or MBetaCD]]
*[[MS222]]
*[[nicardipine]]
*[[Nu6102]]
*[[phenylthiourea|phenylthiourea (PTU)]]
*[[purmorphamine]]
*[[Pyrazoleanthrone]]
*[[R(+)BayK 8644]]
*[[RHC80267]]
*[[RL-3]]
*[[SAG]]
*[[SB-431542]]
*[[TG003]]
*[[Thapsigargin]]
*[[U0126]]
*[[ursodeoxycholic acid]]
*[[Echinomycin]]
*[[Gö 6983]]
*[[phenylhydrazine]]
*[[ω-conotoxin–GVIA]]
*[[flunarizine]]
*[[tetrodotoxin]]
*[[veratridine]]
*[[NBI-27914]]


==Small Molecules Affecting Pathways==
>762 Xenbase articles contain a reference to BAPTA-AM according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
===cAMP===
*[[IBMX]]
*[[RU486]]
 
===CDK/Cyclins===
*[[olomoucine]]
*[[RO-3306]]
 
===ERK/MAPK===
*[[U0126]]
===Folic Acid===
*[[Methotrexate (MTX)]]
 
===JAK/STAT===
*[[AZD1480]]
 
===JNK===
*[[SP600125]]
*[[Pyrazoleanthrone]]
 
===Nitric Oxide===
*[[sodium nitroprusside]]
 
===PDGF===
*[[AG1296]]
*[[AP1510]]
 
===Retinoic Acid===
*[[AGN193109]]
*[[Citral]]
*[[retinoic acid]]
*[[Retinol]]
*[[TTNPB]]
*[[BMS-453]]
 
===Shh===
*[[cyclopamine]]
*[[purmorphamine]]
*[[Vismodegib]]
 
===TGF-beta/BMP===
*[[SB-431542]]
*[[SB505124]]
 
===Thyroid Signaling===
*[[PTU]]
 
===Wnt===
*[[LiCl]]
*[[GSK3-inhibitor IX (BIO)]]
*[[IWR1]]
 
===Epigenetics===
*[[Ex-527]]
 
===Protease Inhibitors===
*[[chymostatin]]
*[[GM6001|GM6001 (MMP inhibitor)]]
*[[o-phenanthroline|o-phenanthroline(MMP inhibitor)]]
*[[BB-94|BB-94 MMP inhibitor]]
*[[GI254023X| GI254023X MMP10 inhibitor]]
 
==Small Molecules affecting Biological Functions & Processes==
===Angiogenesis===
*[[dimethyloxallyl glycine (DMOG)]]
*[[herbimycin A]]
*[[Suramin]]
 
===Apoptosis===
*[[cycloheximide]]
*[[alpha-amanitin]]
*[[Cyclosporin A]]
*[[2,2ʹ-Methylenebis(1,3-cyclohexanedione)]]
*[[NS3694]]
 
===Autophagy===
*[[LY-294002]]
 
===Calcium Signaling===
*[[nifedipine]]
*[[R(+)BayK 8644]]
*[[nicardipine]]
*[[deltamethrin]]
*[[BHQ]]
*[[Thapsigargin]]
 
===Circadian Rhythm===
*[[quinpirole]]
 
===Cytoskeletal Inhibitors===
*[[Cytochalasin B]]
*[[cytochalasin D]]
*[[Colcemide]]
*[[jasplakinolide]] is an activator
*[[latrunculin B]]
*[[taxol]]
*[[taxol|Paclitaxel]]
 
===Cell Cycle, including mitosis===
*[[Colcemide]]
*[[Hydroxyurea]]
*[[olomoucine]]
*[[PD-407824]]
===Cilia===
*[[methylcellulose (MC)]]
 
===DNA Damage/Repair===
*[[etoposide]]
*[[Hydroxyurea]]
 
===DNA Synthesis===
*[[Calyculin A]]
 
===Growth Cone, Filopodia, and other Cytoskeletal projections===
*[[PP2]]
*[[SU6656]]
*[[cytochalasin D]] 0.1 uM Sigma
*[[latrunculin B]] 30nM Sigma
*[[colchicine]] 12.5uM Sigma
*[[nocodazole]] 0.1uM Sigma
*[[RHC80267]]
 
===Hatching===
*[[ouabain]]
 
===Left-Right Patterning===
*[[methylcellulose (MC)]]
 
===Metamorphosis===
*[[3,3,5-triiodothyronine (T3)]]
*[[methimazole]]
*[[propylthiouracil]]
*[[thyroxine (T4)]]
 
===Neurotransmission===
*[[diazepam]]
*[[p-MPPI]]
*[[phaclofen]]
*[[RS67333]]
*[[deltamethrin]]
 
===Protein Recycling===
*[[primaquine]]
 
==Drugs by Gene Class==
 
===Channels, including ATPases===
*[[ouabain]]
*[[AM251]]
*[[AM281]]
*[[LY320135]]
===G Protein Receptors===
*[[purmorphamine]]
===Kinases===
*[[KT 5720]]
*[[olomoucine]]
*[[PD-407824]]
*[[SB 203580]]
*[[Y27632]]
*[[ZM 447439]]
 
===Phosphatases===
*[[Cyclosporin A]]
*[[deltamethrin]]
*[[okadaic acid]]
*[[tautomycin]]
*[[Calyculin A]]
 
===Small GTPases===
 
 
===Protein Synthesis===
*[[anisomycin]] 40uM Sigma
*[[cycloheximide]] 40uM
 
===Retinoids===
*[[TTNPB]] Sigma
 
==Textpresso Small Molecules to Research==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=43038 importazole inhibits importin]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 M119]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 GBG or GBetaGamma or G Protein Beta Gamma]
*[[LY-294002| LY-294002 inhibits PI3K and autophagy]]
 
==Models of Anemia==
*[[Phenylhydrazine]]

Revision as of 07:45, 28 May 2015

Description

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.

Suppliers

Usage Notes

.4uM in .1x NAM

References

>762 Xenbase articles contain a reference to BAPTA-AM according to textpresso