O-phenanthroline and AM251: Difference between pages

Revision as of 07:14, 23 June 2017

Description

AM251, is a CB1 cannabinoid receptor antagonist

- Genes Affected
- cnr1

==Synonyms==AM-251; 183232-66-8; AM 251; UNII-3I4FA44MAI; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide.

Suppliers

Sigma
Tocris

Usage Notes

References

PubChem CID:2125

>9 Xenbase articles contain a reference to AM251 according to textpresso

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 ==Description==
-Synonym: 1,10-Phenanthroline
+AM251, is a CB1 cannabinoid receptor antagonist
+**Genes Affected
-Interacts with MMP
+**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=962200 cnr1]
+==Synonyms==AM-251; 183232-66-8; AM 251; UNII-3I4FA44MAI; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide.
-"o-Phenanthroline is a colorimetric reagent for iron detection. It is also used as a reagent for the solvent extraction of anions. This reagent is slightly soluble in water (3.3 g/l at room temperature) and benzene (14 g/l at room temperature), and fairly soluble in alcohol (540 g/l), acetone, and diluted mineral acids. Its proton dissociation constants are reported to be pKa1=0.70 and pKa2=4.98 (μ=0.1, 25ºC). o-Phenanthroline forms a red chelate with Fe(II) [logβ3=21.1(μ=0.1, 20ºC), λmax=510 nm, ε=1.1x105]. This complex is not easily extracted by organic solvents. The redox potential of FeL33+ -FeL32+ (L: o-phenanthroline) in 1 M H2SO4 is reported to be 1.06 V, and the color of the solution changes from red to pale blue. This reagent also forms colored complexes with Cu, Ni, and Co, and colorless complexes with Cd and Zn. Therefore, o-Phenanthroline can be used as a colorimetric reagent for Cu, Ni, and Co, and as a masking reagent of Cd and Zn. FeL32+ is also utilized for precipitation detection and ion-pair extraction."
+[[File:AM251.png|frame|right|AM251 structure, image from Pubchem]]
-*-Dojindo Product description
+==Suppliers==
+*[http://www.sigmaaldrich.com/catalog/product/sigma/a6226?lang=en&region=US Sigma]
-[[File:o-phenanthroline.png|frame|right|o-phenanthrolin structure, photo from Sigma-Aldrich]]
+*[https://www.tocris.com/dispprod.php?ItemId=2200#.WUwmuuvyuUk Tocris]
-==Genes Affected==
-MMP
-==Suppliers==
-*[http://www.dojindo.com/store/p/677-o-Phenanthroline.html Dojindo]
-*[http://www.sigmaaldrich.com/catalog/product/aldrich/131377?lang=en&region=US Sigma]
 ==Usage Notes==
 ==References==
-*[https://pubchem.ncbi.nlm.nih.gov/ Pubchem]
+*[https://pubchem.ncbi.nlm.nih.gov/compound/am251 PubChem CID:2125]
-*[http://www.xenbase.org/literature/article.do?method=display&articleId=49477 Iwao et al., 2xxxx]
->35 Xenbase articles contain a reference to o-phenanthroline according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
+>9 Xenbase articles contain a reference to AM251 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
-*
 *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]