Olomoucine and AM251: Difference between pages

Revision as of 07:14, 23 June 2017

Description

AM251, is a CB1 cannabinoid receptor antagonist

- Genes Affected
- cnr1

==Synonyms==AM-251; 183232-66-8; AM 251; UNII-3I4FA44MAI; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide.

Suppliers

Sigma
Tocris

Usage Notes

References

PubChem CID:2125

>9 Xenbase articles contain a reference to AM251 according to textpresso

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 ==Description==
-"Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest."
+AM251, is a CB1 cannabinoid receptor antagonist
-*-Sigma product decription
+**Genes Affected
+**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=962200 cnr1]
-[[File:Olomoucine.png|frame|right|Olomoucine structure, photo from Sigma-Aldrich]]
+==Synonyms==AM-251; 183232-66-8; AM 251; UNII-3I4FA44MAI; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide.
+[[File:AM251.png|frame|right|AM251 structure, image from Pubchem]]
-==Genes Affected==
+==Suppliers==
-CDK's
+*[http://www.sigmaaldrich.com/catalog/product/sigma/a6226?lang=en&region=US Sigma]
+*[https://www.tocris.com/dispprod.php?ItemId=2200#.WUwmuuvyuUk Tocris]
-==Suppliers==
-*[http://www.sigmaaldrich.com/catalog/product/sigma/o0886?lang=en&region=US Sigma O0886]
 ==Usage Notes==
-mM
 ==References==
-*[https://pubchem.ncbi.nlm.nih.gov/compound/4592 Pubchem]
+*[https://pubchem.ncbi.nlm.nih.gov/compound/am251 PubChem CID:2125]
-*[http://www.xenbase.org/literature/article.do?method=display&articleId=49376 Edens et al., 2014]
->42 Xenbase articles contain a reference to olomoucine according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
+>9 Xenbase articles contain a reference to AM251 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
-*
 *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]