XB-FEAT-5817007: Difference between revisions
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=nat8l= | =''nat8l''= | ||
This is the community wiki page for the gene ''nat8l'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''nat8l'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=nomenclature changes= | |||
NOV 2019 | |||
This gene represents one of 9 duplicated ''‘nat8’'' genes identified by Xenbase during analysis “Xenopus” v9/10 genome annotation, all on Chromosome 1 in ''X. tropicalis'' and ''X. laevis'', and is true ortholog of the human NAT8L gene. | |||
Note that not all duplications are present in “X. tropicalis”, and “X. laevis” does not always have both .L and .S homeologs. | |||
06.20.2020 | |||
Following HNGC, Xenbase changed name for nat8l from N-acetyltransferase 8-like (GCN5-related, putative) to N-acetyltransferase 8 like | |||
=summary for human NAT8L from NCBI= | |||
This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010] | |||
Latest revision as of 08:58, 30 June 2020
nat8l
This is the community wiki page for the gene nat8l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
NOV 2019 This gene represents one of 9 duplicated ‘nat8’ genes identified by Xenbase during analysis “Xenopus” v9/10 genome annotation, all on Chromosome 1 in X. tropicalis and X. laevis, and is true ortholog of the human NAT8L gene.
Note that not all duplications are present in “X. tropicalis”, and “X. laevis” does not always have both .L and .S homeologs.
06.20.2020
Following HNGC, Xenbase changed name for nat8l from N-acetyltransferase 8-like (GCN5-related, putative) to N-acetyltransferase 8 like
summary for human NAT8L from NCBI
This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]