PP2 and Tyrphostin AG 1478: Difference between pages

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==Description==
==Description==
Synonym: 4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, AG 1879
Tyrphostin AG 1478
[[File:LatrunculinB.structure.png|frame|right|Latrunculin B structure, image from PubChem]]


"PP2 is a selective inhibitor of Src-family tyrosine kinases with >10,000-fold selectivity over ZAP-70 and JAK2."
==Alternative names==
*-Sigma Product Description
*  N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
 
* AG 1478
[[File:PP2.png|frame|right|PP2 structure, photo from Sigma-Aldrich]]
 
==Genes Affected==
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=489819 src]


==Suppliers==
==Suppliers==
*[http://www.emdmillipore.com/US/en/product/PP2---CAS-172889-27-9---Calbiochem,EMD_BIO-529573?bd=1 Calbiochem is now EMD Millipore]
*[http://www.sigmaaldrich.com/catalog/product/sigma/t4182?lang=en&region=US Sigma]
*[http://www.sigmaaldrich.com/catalog/product/sigma/p0042?lang=en&region=US Sigma]


==Usage Notes==
==Usage Notes==
1uM in cell culture media, up to 10mM in certain applications


==References==
==References==
*[https://pubchem.ncbi.nlm.nih.gov/compound/4878 PubChem]
*[https://pubchem.ncbi.nlm.nih.gov/compound/2051 NCBI PubChem CID:2051]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=1490 Robles et al., 2005]
*[http://www.xenbase.org/literature/article.do?articleId=43043&method=display Xue at al., 2012]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=9003 Browaeys-Poly et al. 2001]


>18 Xenbase articles contain a reference to PP2 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
> 15 Xenbase articles contain a reference to Tyrphostin AG 1478 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
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*
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]

Revision as of 10:46, 18 August 2016

Description

Tyrphostin AG 1478

Latrunculin B structure, image from PubChem

Alternative names

  • N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
  • AG 1478

Suppliers

Usage Notes

References

> 15 Xenbase articles contain a reference to Tyrphostin AG 1478 according to textpresso