XB-FEAT-5848002

XB5848002

This is the community wiki page for the gene XB5848002 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

notes on synonyms

XB5848002, also known as 'loc100494211', and is referred to as 'Bighead' in this article. XB-ART-55302 Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.

When fully characterized, the gene name and synonyms will be updated to reflect what kind of protien/gene family this gene represents.

protein function and phenotype notes

Bighead is a secreted protein that inhibits Wnt by causing the endocytosis and degradation in lysosomes of the Wnt coreceptor Lrp6. Its overexpression induces embryos with larger heads, and its knockdown reduces head development through the regulation of Wnt signaling.

source: Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.