Vismodegib: Difference between revisions
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Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893) | Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893) | ||
PubChem CID: 24776445 | |||
Molecular Formula: C19H14Cl2N2O3S | |||
Molecular Weight: 421.292 g/mol | |||
InChI Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N | |||
Revision as of 08:58, 29 November 2017
Vismodegib
Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively."
Function: Shh (sonic hedgehog) signal pathway inhibitor.
Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893)
PubChem CID: 24776445
Molecular Formula: C19H14Cl2N2O3S
Molecular Weight: 421.292 g/mol
InChI Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N