Cyclosporin A: Difference between revisions

From XenWiki
Jump to navigation Jump to search
imported>Kevin
No edit summary
imported>Kevin
No edit summary
Line 8: Line 8:


==Genes Affected==
==Genes Affected==
 
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=952298 ppp3ca (Calcineurin)]
==Suppliers==
==Suppliers==
*[http://www.emdmillipore.com/US/en/product/Cyclosporin-A%2C-Tolypocladium-inflatum---CAS-59865-13-3---Calbiochem,EMD_BIO-239835?RedirectedFrom=http://www.emdmillipore.com/products/EMD_BIO-239835 Calbiochem]
*[http://www.emdmillipore.com/US/en/product/Cyclosporin-A%2C-Tolypocladium-inflatum---CAS-59865-13-3---Calbiochem,EMD_BIO-239835?RedirectedFrom=http://www.emdmillipore.com/products/EMD_BIO-239835 Calbiochem]

Revision as of 08:10, 13 October 2015

Description

"Cyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells."

  • -Calbiochem Product Description


Synonym CsA

Cyclosporin A structure, photo from Pubchem

Genes Affected

Suppliers

Usage Notes

References

>161 Xenbase articles contain a reference to Cyclosporin A according to textpresso