XB-FEAT-5904136: Difference between revisions
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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. '''The olfactory receptor gene family is the largest in the genome'''. '''The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.''' This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015] | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. '''The olfactory receptor gene family is the largest in the genome'''. '''The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.''' This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015] | ||
=orthology= | =orthology= | ||
Note that NCBi acknowledges that "The nomenclature assigned to the olfactory receptor genes and proteins for this [humans] is independent of other organisms", so | Note that NCBi acknowledges that "The nomenclature assigned to the olfactory receptor genes and proteins for this [humans] is independent of other organisms", so the Xenopus or1s1 is very unlikely to be a true ortholog of human OR1S1. | ||
Latest revision as of 12:19, 8 March 2022
or1s1
This is the community wiki page for the gene or1s1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
01/15/2015 Human name has changed for Entrez Gene: 219959. From olfactory receptor, family 1, subfamily S, member 1 to olfactory receptor, family 1, subfamily S, member 1 (gene/pseudogene)
3/4/2022
removed ‘(gene/pseudogene)’ from gene name as human OR1S1 gene has validated gene type as ‘protein coding’, and other orthologs are also validated protein coding genes
summary for human OR1S1 from NCBI
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
orthology
Note that NCBi acknowledges that "The nomenclature assigned to the olfactory receptor genes and proteins for this [humans] is independent of other organisms", so the Xenopus or1s1 is very unlikely to be a true ortholog of human OR1S1.