Suramin: Difference between revisions

Revision as of 13:43, 2 July 2015

Description

synonyms: Germanin; Naganol; Naphuride; Belganyl; Suramine "Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity."

-Sigma product description

Genes Affected

Topoisomerase II

Suppliers

Bayer AG
Sigma

Usage Notes

150mM in culture

References

>209 Xenbase articles contain a reference to suramin according to textpresso

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@@ Line 1: / Line 1: @@
 ==Description==
-[[File:______|frame|right|_______ structure, photo from Sigma-Aldrich]]
+synonyms: Germanin; Naganol; Naphuride; Belganyl; Suramine
+"Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity."
+*-Sigma product description
+[[File:suramin.png|frame|right|suramin structure, photo from pubchem]]
 ==Genes Affected==
+Topoisomerase II
 ==Suppliers==
-*[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENBASE]
+*Bayer AG
+*[http://www.sigmaaldrich.com/catalog/product/sigma/s2671?lang=en&region=US Sigma]
 ==Usage Notes==
+mM in culture
 ==References==
-*[https://pubchem.ncbi.nlm.nih.gov/ Pubchem]
+*[https://www.ncbi.nlm.nih.gov/pccompound?term=suramin Pubchem]
-*[http://www.xenbase.org/literature/article.do?method=display&articleId=__________ ____ et al., 2xxxx]
+*[http://www.xenbase.org/literature/article.do?method=display&articleId=12409]
+*[http://www.xenbase.org/literature/article.do?method=display&articleId=16506]
->___ Xenbase articles contain a reference to _____ according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
+>209 Xenbase articles contain a reference to suramin according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
 *
 *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]